Adaptations of the human placenta to hypoxia: opportunities for interventions in fetal growth restriction

A Colson, P Sonveaux, F Debiève… - Human reproduction …, 2021 - academic.oup.com
BACKGROUND The placenta is the functional interface between the mother and the fetus
during pregnancy, and a critical determinant of fetal growth and life-long health. In the first …

Hypoxia‐inducible factor 2 alpha impairs human cytotrophoblast syncytialization: new insights into placental dysfunction and fetal growth restriction

A Colson, CL Depoix, P Baldin, C Hubinont… - The FASEB …, 2020 - Wiley Online Library
Insufficient remodeling of uterine arteries causes pregnancy‐related diseases, including
fetal growth restriction and preeclampsia. In these situations, reduced maternal blood flow in …

The long noncoding RNA cancer susceptibility candidate 9 promotes nasopharyngeal carcinogenesis via stabilizing HIF1α

X Su, G Li, W Liu - DNA and Cell Biology, 2017 - liebertpub.com
Increasing evidence has suggested that long noncoding RNAs (lncRNAs) play critical roles
in cancer development. Nasopharyngeal carcinoma (NPC) is a disease with high incidence …

HIF1A and EPAS1 potentiate hypoxia-induced upregulation of inhibin alpha chain expression in human term cytotrophoblasts in vitro

CL Depoix, I De Selliers, C Hubinont… - MHR: Basic science of …, 2017 - academic.oup.com
Abstract Study Question Are hypoxia-inducible factors (HIF) responsible for the potentiation
of inhibin alpha subunit (INHA) gene expression in primary cultures of human term …

Small-molecule α-lipoic acid targets ELK1 to balance human neutrophil and erythrocyte differentiation

Y Zhang, Y Zhou, X Li, X Pan, J Bai, Y Chen… - Stem Cell Research & …, 2024 - Springer
Background Erythroid and myeloid differentiation disorders are commonly occurred in
leukemia. Given that the relationship between erythroid and myeloid lineages is still unclear …

Is 8% O2 more normoxic than 21% O2 for long-term in vitro cultures of human primary term cytotrophoblasts?

CL Depoix, F Haegeman, F Debiève… - MHR: Basic science of …, 2018 - academic.oup.com
Abstract STUDY QUESTION Is 8% O2 a better percentage of atmospheric oxygen for long-
term cultures of human primary term cytotrophoblasts than the conventional 21% O2 …

[PDF][PDF] Ontology groups representing angiogenesis and blood vessels development are highly up-regulated during porcine oviductal epithelial cells long-term real …

MJ Nawrocki, P Celichowski, M Jankowski… - Medical Journal of Cell …, 2018 - sciendo.com
The morphological and biochemical modification of oviductal epithelial cells (OECs) belongs
to the group of compound processes responsible for proper oocyte transport and successful …

Isolation of primary cytotrophoblasts from human placenta at term

A Colson, CL Depoix, C Hubinont, F Debiève - Bio-protocol, 2021 - bio-protocol.org
The placenta is a multifaceted organ, fulfilling critical functions for the fetus and the mother.
Therefore, it is a critical regulator of the pregnancy, and its dysfunction leads to diseases …

[PDF][PDF] Модуляция экспрессии гена HIF2A в плюрипотентных стволовых клетках человека с использованием системы CRISPR/Cas9

ИС Захарова - icgbio.ru
Актуальность исследования. В процессе развития у многоклеточных организмов
сформировались системы регуляции гомеостатического баланса кислорода в тканях. В …

[PDF][PDF] Hypoxia-inducible factor 2 alpha impairs human cytotrophoblast syncytialization: new insights in placental dysfunction and fetal growth restriction

A Colson, CL Depoix, P Baldin, C Hubinont… - dial.uclouvain.be
Insufficient remodeling of uterine arteries causes pregnancy-related diseases, including fetal
growth restriction and preeclampsia. In these situations, reduced maternal blood flow in the …