Interactions between bacterial and phage communities in natural environments

A Chevallereau, BJ Pons, S van Houte… - Nature Reviews …, 2022 - nature.com
We commonly acknowledge that bacterial viruses (phages) shape the composition and
evolution of bacterial communities in nature and therefore have important roles in ecosystem …

[HTML][HTML] Strategies to overcome the main challenges of the use of CRISPR/Cas9 as a replacement for cancer therapy

MF Rasul, BM Hussen, A Salihi, BS Ismael, PJ Jalal… - Molecular Cancer, 2022 - Springer
CRISPR/Cas9 (clustered regularly interspaced short palindromic repeats-associated protein
9) shows the opportunity to treat a diverse array of untreated various genetic and …

Phage cocktail development for bacteriophage therapy: toward improving spectrum of activity breadth and depth

ST Abedon, KM Danis-Wlodarczyk, DJ Wozniak - Pharmaceuticals, 2021 - mdpi.com
Phage therapy is the use of bacterial viruses as antibacterial agents. A primary
consideration for commercial development of phages for phage therapy is the number of …

Understanding the impacts of bacteriophage viruses: from laboratory evolution to natural ecosystems

B Koskella, CA Hernandez… - Annual Review of …, 2022 - annualreviews.org
Viruses of bacteria (bacteriophages or phage) have broad effects on bacterial ecology and
evolution in nature that mediate microbial interactions, shape bacterial diversity, and …

Bacteriostatic antibiotics promote CRISPR-Cas adaptive immunity by enabling increased spacer acquisition

T Dimitriu, E Kurilovich, U Łapińska, K Severinov… - Cell host & …, 2022 - cell.com
Phages impose strong selection on bacteria to evolve resistance against viral predation.
Bacteria can rapidly evolve phage resistance via receptor mutation or using their CRISPR …

Coevolution between bacterial CRISPR-Cas systems and their bacteriophages

BNJ Watson, JA Steens, RHJ Staals, ER Westra… - Cell host & …, 2021 - cell.com
CRISPR-Cas systems provide bacteria and archaea with adaptive, heritable immunity
against their viruses (bacteriophages and phages) and other parasitic genetic elements …

Genome-driven elucidation of phage-host interplay and impact of phage resistance evolution on bacterial fitness

P Markwitz, C Lood, T Olszak, V van Noort… - The ISME …, 2022 - academic.oup.com
When considering the interactions between bacteriophages and their host, the issue of
phage-resistance emergence is a key element in understanding the ecological impact of …

BacSeq: A user-friendly automated pipeline for whole-genome sequence analysis of bacterial genomes

A Chukamnerd, K Jeenkeawpiam, S Chusri… - Microorganisms, 2023 - mdpi.com
Whole-genome sequencing (WGS) of bacterial pathogens is widely conducted in
microbiological, medical, and clinical research to explore genetic insights that could impact …

It is unclear how important CRISPR-Cas systems are for protecting natural populations of bacteria against infections by mobile genetic elements

ER Westra, BR Levin - … of the National Academy of Sciences, 2020 - National Acad Sciences
Articles on CRISPR commonly open with some variant of the phrase “these short
palindromic repeats and their associated endonucleases (Cas) are an adaptive immune …

The effect of phage genetic diversity on bacterial resistance evolution

JM Broniewski, S Meaden, S Paterson… - The ISME …, 2020 - academic.oup.com
CRISPR-Cas adaptive immune systems are found in bacteria and archaea and provide
defence against phage by inserting phage-derived sequences into CRISPR loci on the host …