Definitive haematopoiesis is the process by which haematopoietic stem cells, located in the
bone marrow, generate all haematopoietic cell lineages in healthy adults. Although highly …

Inflammation is a key driver of the progression of pre-leukemic myeloid conditions, such as
clonal hematopoiesis of indeterminate potential (CHIP) and clonal cytopenia of …

Hematopoietic stem cells (HSCs) and multipotent progenitors (MPPs) generate all cells of
the blood system. Despite their multipotency, MPPs display poorly understood lineage bias …

Both cell-intrinsic and niche-derived, cell-extrinsic cues drive the specification of
hematopoietic multipotent progenitors (MPPs) in the bone marrow, which comprise …

Neonates are highly susceptible to inflammation and infection. Here, we investigate how late
fetal liver (FL) mouse hematopoietic stem and progenitor cells (HSPCs) respond to …

Myeloblast expansion is a hallmark of disease progression and comprises CD34+
hematopoietic stem and progenitor cells (HSPC). How this compartment evolves during …

Hematopoietic stem cells (HSCs) are a rare, long-lived and multipotent population that give
rise to majority of blood cells and some tissue-resident immune cells. There is growing …

Background A complex interrelationship exists between Heart Failure (HF) and chronic
kidney disease (CKD). This study aims to clarify the molecular mechanisms of the organ-to …

Hematopoietic aging is characterized by chronic inflammation associated with myeloid bias,
HSC accumulation, and functional HSC impairment. Yet it remains unclear how …

Severe infections such as malaria are on the rise worldwide, driven by both climate change
and increasing drug-resistance. It is therefore paramount that we better understand how the …