Advances in develo** novel therapeutic strategies for Alzheimer's disease

J Cao, J Hou, J **, D Cai - Molecular neurodegeneration, 2018 - Springer
Abstract Alzheimer's Disease (AD), the most prevalent neurodegenerative disease of aging,
affects one in eight older Americans. Nearly all drug treatments tested for AD today have …

Modulating human memory via entrainment of brain oscillations

S Hanslmayr, N Axmacher, CS Inman - Trends in neurosciences, 2019 - cell.com
In the human brain, oscillations occur during neural processes that are relevant for memory.
This has been demonstrated by a plethora of studies relating memory processes to specific …

Forty-hertz light stimulation does not entrain native gamma oscillations in Alzheimer's disease model mice

M Soula, A Martín-Ávila, Y Zhang, A Dhingra… - Nature …, 2023 - nature.com
There is a demand for noninvasive methods to ameliorate disease. We investigated whether
40-Hz flickering light entrains gamma oscillations and suppresses amyloid-β in the brains of …

[HTML][HTML] Gamma entrainment binds higher-order brain regions and offers neuroprotection

C Adaikkan, SJ Middleton, A Marco, PC Pao, H Mathys… - Neuron, 2019 - cell.com
Neuronal and synaptic loss is characteristic in many neurodegenerative diseases, such as
frontotemporal dementia and Alzheimer's disease. Recently, we showed that inducing …

Gamma entrainment: impact on neurocircuits, glia, and therapeutic opportunities

C Adaikkan, LH Tsai - Trends in Neurosciences, 2020 - cell.com
Studies have shown that gamma oscillations (30–100 Hz) are relevant for neurocircuit
function, behavior, and memory. To examine a possible causal contribution of gamma …

40 Hz light flickering promotes sleep through cortical adenosine signaling

X Zhou, Y He, T Xu, Z Wu, W Guo, X Xu, Y Liu, Y Zhang… - Cell Research, 2024 - nature.com
Flickering light stimulation has emerged as a promising non-invasive neuromodulation
strategy to alleviate neuropsychiatric disorders. However, the lack of a neurochemical …

A feasibility trial of gamma sensory flicker for patients with prodromal Alzheimer's disease

Q He, KM Colon‐Motas, AF Pybus… - … Research & Clinical …, 2021 - Wiley Online Library
Introduction We and collaborators discovered that flickering lights and sound at gamma
frequency (40 Hz) reduce Alzheimer's disease (AD) pathology and alter immune cells and …

Non-invasive photobiomodulation treatment in an Alzheimer Disease-like transgenic rat model

L Yang, C Wu, E Parker, Y Li, Y Dong, L Tucker… - …, 2022 - pmc.ncbi.nlm.nih.gov
Alzheimer's disease (AD) is the most common form of dementia in the elderly, causing
neuronal degeneration and cognitive deficits that significantly impair independence and …

Cognitive and neuropathophysiological outcomes of gamma-tACS in dementia: A systematic review

V Manippa, A Palmisano, MA Nitsche, M Filardi… - Neuropsychology …, 2024 - Springer
Despite the numerous pharmacological interventions targeting dementia, no disease-
modifying therapy is available, and the prognosis remains unfavorable. A promising …

[HTML][HTML] Photobiomodulation for Alzheimer's disease: has the light dawned?

MR Hamblin - Photonics, 2019 - mdpi.com
Next to cancer, Alzheimer's disease (AD) and dementia is probably the most worrying health
problem facing the Western world today. A large number of clinical trials have failed to show …