The stria vascularis (SV) is a highly vascularized tissue lining the lateral wall of the cochlea.
The SV maintains cochlear fluid homeostasis, generating the endocochlear potential that is …

The role of the mammalian auditory olivocochlear efferent system in hearing has long been
the subject of debate. Its ability to protect against damaging noise exposure is clear, but …

There are multiple etiologies and phenotypes of age-related hearing loss or presbyacusis. In
this review we summarize findings from animal and human studies of presbyacusis …

Significance: The stria vascularis, located in the inner ear, consists of three layers, one of
which is the blood–labyrinth barrier (BLB). It is formed by endothelial cells, sealed together …

Age-related hearing loss is difficult to study in humans because multiple genetic and
environmental risk factors may contribute to pathology and cochlear function declines in …

The inbred mouse strain CBA/CaJ is a frequently used animal model of age-related hearing
loss in humans. These mice display significant hearing loss at a relatively advanced age …

Aging leads to degeneration of the peripheral and central auditory systems, hearing loss,
and difficulty understanding sounds in noise. Aging is also associated with changes in …

Age-related hearing loss affects a large and growing segment of the population, with
profound impacts on quality of life. Age-related pathology of the cochlea—the mammalian …

Age-related hearing loss (ARHL) is a public health problem that has been associated with
negative health outcomes ranging from increased frailty to an elevated risk of develo** …

Deer mice (genus Peromyscus) are an emerging model for aging studies due to their
longevity relative to rodents of similar size. Although Peromyscus species are well …