Thrombospondin-1 is a secreted matricellular glycoprotein that modulates cell behavior by
interacting with components of the extracellular matrix and with several cell surface …

Interleukin (IL)-36 cytokines are members of the IL-1 superfamily, which consists of three
agonists (IL-36α, IL-36β and IL-36γ) and an IL-36 receptor antagonist (IL-36Ra). IL-36 …

Limited proteolysis of thrombospondins is a powerful mechanism to ensure dynamic tuning
of their activities in the extracellular space. Thrombospondins are multifunctional …

The IL-36 family of cytokines were identified in the early 2000's as a new subfamily of the IL-
1 cytokine family, and since then, the role of IL-36 cytokines during various inflammatory …

Matricellular proteins comprise a diverse group of molecular entities secreted into the
extracellular space. They interact with the extracellular matrix (ECM), integrins, and other …

Introduction Klebsiella pneumoniae (Kp) is a common cause of hospital-acquired
pneumonia. Although previous studies have suggested that evasion of phagocytic uptake is …

The structural composition, integrity and regular curvature of the cornea contribute to the
maintenance of its transparency and vision. Disruption of its integrity caused by injury results …

Introduction Anti-N-methyl-D-aspartate receptor encephalitis (anti-NMDARE) is a rare
autoimmune disease, and the peripheral immune characteristics associated with anti …

Unfolded protein response (UPR) signaling and endoplasmic reticulum (ER) stress have
been linked to pulmonary fibrosis. However, the relationship between UPR status and …

Objectives Bacterial pneumonia is a common serious infectious disease with high morbidity
and mortality. Prokineticin 2 (PK2) has recently been identified as a novel immunomodulator …