Not-so-opposite ends of the spectrum: CD8+ T cell dysfunction across chronic infection, cancer and autoimmunity
CD8+ T cells are critical mediators of cytotoxic effector function in infection, cancer and
autoimmunity. In cancer and chronic viral infection, CD8+ T cells undergo a progressive loss …
autoimmunity. In cancer and chronic viral infection, CD8+ T cells undergo a progressive loss …
Immunometabolism and HIV-1 pathogenesis: food for thought
A Saez-Cirion, I Sereti - Nature reviews immunology, 2021 - nature.com
Antiretroviral therapies efficiently block HIV-1 replication but need to be maintained for life.
Moreover, chronic inflammation is a hallmark of HIV-1 infection that persists despite …
Moreover, chronic inflammation is a hallmark of HIV-1 infection that persists despite …
Optimal maturation of the SIV-specific CD8+ T cell response after primary infection is associated with natural control of SIV: ANRS SIC study
C Passaes, A Millet, V Madelain, V Monceaux, A David… - Cell Reports, 2020 - cell.com
Highly efficient CD8+ T cells are associated with natural HIV control, but it has remained
unclear how these cells are generated and maintained. We have used a macaque model of …
unclear how these cells are generated and maintained. We have used a macaque model of …
Role of Circulating T Follicular Helper Cells and Stem-Like Memory CD4+ T Cells in the Pathogenesis of HIV-2 Infection and Disease Progression
SM Ponnan, KK Vidyavijayan… - Frontiers in …, 2021 - frontiersin.org
CD4+ T cells are critical players in the host adaptive immune response. Emerging evidence
suggests that certain CD4+ T cell subsets contribute significantly to the production of …
suggests that certain CD4+ T cell subsets contribute significantly to the production of …
Loss of TCF-1 regulates production of noncanonical Tregs in a prion-like manner
R Harris, M Mammadli, M Karimi - bioRxiv, 2021 - biorxiv.org
Regulatory T cells (Tregs) are suppressive immune cells used for a variety of clinical and
therapeutic applications. Canonical Tregs express CD4, FOXP3, and CD25, which are …
therapeutic applications. Canonical Tregs express CD4, FOXP3, and CD25, which are …