Cancer cells typically heavily rely on the G2/M checkpoint to survive endogenous and
exogenous DNA damage, such as genotoxic stress due to genome instability or radiation …

The DNA damage response (DDR) is critical for the maintenance of genomic stability by
sensing DNA damage, regulating cell cycle and initiating DNA repair. Drugs targeting DDR …

Fanconi anemia (FA) signaling, a key genomic maintenance pathway, is activated in
response to replication stress. Here, we report that phosphorylation of the pivotal pathway …

DNA damage response (DDR) deficiency has been one of the emerging targets in treating
breast cancer in recent years. On the one hand, DDR coordinates cell cycle and signal …

Abstract Background Dysregulated Notch signalling contributes to breast cancer
development and progression, but validated tools to measure the level of Notch signalling in …

Despite the success of antiestrogens in extending overall survival of patients with estrogen
receptor positive (ER+) breast tumors, resistance to these therapies is prevalent. ER+ tumors …

Purpose WEE1 is a crucial kinase involved in the regulation of G2/M checkpoint within the
cell cycle. This article aims to comprehensively review the existing knowledge on the …

Cell cycle checkpoint kinases serve as important therapeutic targets for various cancers.
When they are inhibited by small molecules, checkpoint abrogation can induce cell death or …

We sought to evaluate the efficacy of WEE1 inhibitor adavosertib in patients with solid tumor
malignancies (cohort A) and clear cell renal cell carcinoma (ccRCC; cohort B) …

The use of DNA-damaging agents such as radiotherapy and chemotherapy has been a
mainstay treatment protocol for many cancers, including lung and prostate. Recently, FDA …