Heterotrimeric guanine-nucleotide-binding regulatory proteins (G-proteins) mainly relay the
information from G-protein-coupled receptors (GPCRs) on the plasma membrane to the …

Activation of trimeric G proteins has been traditionally viewed as the exclusive job of G
protein-coupled receptors (GPCRs). This view has been challenged by the discovery of non …

Ric-8A (resistance to inhibitors of cholinesterase 8A) and Ric-8B are guanine nucleotide
exchange factors that enhance different heterotrimeric guanine nucleotide–binding protein …

We have shown that resistance to inhibitors of cholinesterase 8 (Ric-8) proteins regulate an
early step of heterotrimeric G protein α (Gα) subunit biosynthesis. Here, mammalian and …

Mammalian Ric-8 proteins act as chaperones to regulate the cellular abundance of
heterotrimeric G protein α subunits. The Ric-8A isoform chaperones Gαi/o, Gα12/13, and …

ABSTRACT Gα q βγ heterotrimer (G q), an important mediator in the pathology of airway
disease, plays a central role in bronchoconstriction and airway remodeling, including airway …

Neurotransmitters signal via G protein coupled receptors (GPCRs) to modulate activity of
neurons and muscles. C. elegans has∼ 150 G protein coupled neuropeptide receptor …

Although bioinformatic analysis of the increasing numbers of diverse genome sequences
and amount of functional data has provided insight into the evolution of signaling networks …

Resistance to inhibitors of cholinesterase 8 proteins (Ric-8A and Ric-8B) collectively bind
the four classes of heterotrimeric G protein α subunits. Ric-8A and Ric-8B act as non …

Canonical signal transduction via heterotrimeric G proteins is spatially and temporally
restricted, that is, triggered exclusively at the plasma membrane (PM), only by agonist …