Small heat shock proteins: Simplicity meets complexity
M Haslbeck, S Weinkauf, J Buchner - Journal of Biological Chemistry, 2019 - ASBMB
Small heat shock proteins (sHsps) are a ubiquitous and ancient family of ATP-independent
molecular chaperones. A key characteristic of sHsps is that they exist in ensembles of iso …
molecular chaperones. A key characteristic of sHsps is that they exist in ensembles of iso …
The chaperone-assisted selective autophagy complex dynamics and dysfunctions
B Tedesco, L Vendredy, V Timmerman, A Poletti - Autophagy, 2023 - Taylor & Francis
Each protein must be synthesized with the correct amino acid sequence, folded into its
native structure, and transported to a relevant subcellular location and protein complex. If …
native structure, and transported to a relevant subcellular location and protein complex. If …
Small heat shock proteins operate as molecular chaperones in the mitochondrial intermembrane space
Mitochondria are complex organelles with different compartments, each harbouring their
own protein quality control factors. While chaperones of the mitochondrial matrix are well …
own protein quality control factors. While chaperones of the mitochondrial matrix are well …
Heat-shock chaperone HSPB1 regulates cytoplasmic TDP-43 phase separation and liquid-to-gel transition
While acetylated, RNA-binding-deficient TDP-43 reversibly phase separates within nuclei
into complex droplets (anisosomes) comprised of TDP-43-containing liquid outer shells and …
into complex droplets (anisosomes) comprised of TDP-43-containing liquid outer shells and …
A surveillance function of the HSPB8-BAG3-HSP70 chaperone complex ensures stress granule integrity and dynamism
M Ganassi, D Mateju, I Bigi, L Mediani, I Poser, HO Lee… - Molecular cell, 2016 - cell.com
Stress granules (SGs) are ribonucleoprotein complexes induced by stress. They sequester
mRNAs and disassemble when the stress subsides, allowing translation restoration. In …
mRNAs and disassemble when the stress subsides, allowing translation restoration. In …
ATP7A-related copper transport diseases—emerging concepts and future trends
SG Kaler - Nature reviews Neurology, 2011 - nature.com
This Review summarizes recent advances in understanding copper-transporting ATPase 1
(ATP7A), and examines the neurological phenotypes associated with dysfunction of this …
(ATP7A), and examines the neurological phenotypes associated with dysfunction of this …
Modulation of neurodegeneration by molecular chaperones
PJ Muchowski, JL Wacker - Nature Reviews Neuroscience, 2005 - nature.com
Many neurodegenerative disorders are characterized by conformational changes in proteins
that result in misfolding, aggregation and intra-or extra-neuronal accumulation of amyloid …
that result in misfolding, aggregation and intra-or extra-neuronal accumulation of amyloid …
Large potentials of small heat shock proteins
Modern classification of the family of human small heat shock proteins (the so-called HSPB)
is presented, and the structure and properties of three members of this family are analyzed …
is presented, and the structure and properties of three members of this family are analyzed …
Role of axonal transport in neurodegenerative diseases
Many major human neurodegenerative diseases, including Alzheimer's disease,
Parkinson's disease, and amyotrophic lateral sclerosis (ALS), display axonal pathologies …
Parkinson's disease, and amyotrophic lateral sclerosis (ALS), display axonal pathologies …
[HTML][HTML] Exome sequence analysis suggests that genetic burden contributes to phenotypic variability and complex neuropathy
Summary Charcot-Marie-Tooth (CMT) disease is a clinically and genetically heterogeneous
distal symmetric polyneuropathy. Whole-exome sequencing (WES) of 40 individuals from 37 …
distal symmetric polyneuropathy. Whole-exome sequencing (WES) of 40 individuals from 37 …