In recent years, an increasingly more in depth understanding of tumor metabolism in
tumorigenesis, tumor growth, metastasis, and prognosis has been achieved. The broad …

CD4+ T cells are effector T cells (Teffs) produced by the differentiation of initial T cells in
peripheral lymphoid tissue after being attacked by antigens, and have an indispensable role …

Simple Summary There is clear evidence that inflammation can contribute to the
development of cancers, but the underlying mechanisms are not fully understood. This …

Systemic autoimmune diseases are characteristically associated with aberrant autoreactive
innate and adaptive immune responses that lead to tissue damage and increased morbidity …

Metformin has been a long-standing prescribed drug for treatment of type 2 diabetes (T2D)
and its beneficial effects on virus infection, autoimmune diseases, aging and cancers are …

Metabolic and inflammatory pathways are highly interdependent, and both systems are
dysregulated in Type 2 diabetes (T2D). T2D is associated with pre-activated inflammatory …

Chronic exposure to high glucose inside the human body helps in the progression of cancer
by activating various signaling pathways including PI3K, Akt, mTOR, Ras, Raf, MAPK, and …

Introduction Despite the ability of cancer cells to survive glucose deprivation, most studies
on anti-cancer effect of metformin explored its impact on glucose metabolism. No study ever …

More and more evidence shows that metabolic reprogramming is closely related to the
occurrence of AD. The metabolic conversion of oxidative phosphorylation into glycolysis will …