Multiple modes of cell death have been identified, each with a unique function and each
induced in a setting-dependent manner. As billions of cells die during mammalian …

One of the most transformative developments in neurogastroenterology is the realization that
many functions normally attributed to enteric neurons involve interactions with enteric glial …

Caspase-dependent apoptosis accounts for approximately 90% of homeostatic cell turnover
in the body, and regulates inflammation, cell proliferation, and tissue regeneration,–. How …

Pyroptosis is a form of lytic inflammatory cell death driven by inflammatory caspase‐1,
caspase‐4, caspase‐5 and caspase‐11. These caspases cleave and activate the pore …

Nearly every tissue in the body undergoes routine turnover of cells as part of normal healthy
living. The majority of these cells undergoing turnover die via apoptosis, and then are rapidly …

The connexin family of channel-forming proteins is present in every tissue type in the human
anatomy. Connexins are best known for forming clustered intercellular channels, structurally …

Abstract Pannexin-1 (Panx1) channels have been shown to regulate leukocyte trafficking
and tissue inflammation but the mechanism of Panx1 in chronic vascular diseases like …

Membrane transport is a fundamental means to control basic cellular processes such as
apoptosis, inflammation, and neurodegeneration and is mediated by a number of …

Evidence suggests that spironolactone, a nonselective mineralocorticoid receptor (MR)
antagonist, modulates alcohol seeking and consumption. Therefore, spironolactone may …

Over the past several decades a large amount of data have established that glial cells, the
main cell population in the brain, dynamically interact with neurons and thus impact their …