More than 1 out of 10 women worldwide are diagnosed with polycystic ovary syndrome
(PCOS), the leading cause of female reproductive and metabolic dysfunction. Despite its …

The initiation and maintenance of reproductive capacity in humans is dependent on pulsatile
secretion of the hypothalamic hormone GnRH. Congenital hypogonadotropic hypogonadism …

Reproduction is controlled by the hypothalamic-pituitary-gonadal (HPG) axis. Gonadotropin-
releasing hormone (GnRH) neurons play a central role in this axis through production of …

Hypothalamic kisspeptin neurons serve as the nodal regulatory centre of reproductive
function. These neurons are subjected to a plethora of regulatory factors that ultimately affect …

The gonadotropin-releasing hormone (GnRH) pulse is fundamental for mammalian
reproduction: GnRH pulse regimens are needed as therapies for infertile women as …

The concept that different systems control episodic and surge secretion of gonadotropin‐
releasing hormone (GnRH) was well established by the time that GnRH was identified and …

The mechanism by which arcuate nucleus kisspeptin (ARN KISS) neurons co-expressing
glutamate, neurokinin B, and dynorphin intermittently synchronize their activity to generate …

The pulsatile release of GnRH and LH secretion is essential for fertility in all mammals.
Pulses of LH occur approximately every hour in follicular-phase females and every 2 to 3 …

In the past decade since kisspeptin/neurokinin B/dynorphin (KNDy) cells were first identified
in the mammalian hypothalamus, a plethora of new research has emerged adding insights …

The mechanisms underlying the homeostatic estrogen negative feedback pathway central to
mammalian fertility have remained unresolved. Direct measurement of gonadotropin …