Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight?

W Filipowicz, SN Bhattacharyya… - Nature reviews …, 2008 - nature.com
MicroRNAs constitute a large family of small, approximately 21-nucleotide-long, non-coding
RNAs that have emerged as key post-transcriptional regulators of gene expression in …

The gap gene network

J Jaeger - Cellular and Molecular Life Sciences, 2011 - Springer
Gap genes are involved in segment determination during the early development of the fruit
fly Drosophila melanogaster as well as in other insects. This review attempts to synthesize …

Screening cell–cell communication in spatial transcriptomics via collective optimal transport

Z Cang, Y Zhao, AA Almet, A Stabell, R Ramos… - Nature …, 2023 - nature.com
Spatial transcriptomic technologies and spatially annotated single-cell RNA sequencing
datasets provide unprecedented opportunities to dissect cell–cell communication (CCC) …

A survey on incomplete multiview clustering

J Wen, Z Zhang, L Fei, B Zhang, Y Xu… - IEEE Transactions on …, 2022 - ieeexplore.ieee.org
Conventional multiview clustering seeks to partition data into respective groups based on
the assumption that all views are fully observed. However, in practical applications, such as …

Transcriptional coupling of distant regulatory genes in living embryos

M Levo, J Raimundo, XY Bing, Z Sisco, PJ Batut… - Nature, 2022 - nature.com
The prevailing view of metazoan gene regulation is that individual genes are independently
regulated by their own dedicated sets of transcriptional enhancers. Past studies have …

Construction of a 3D whole organism spatial atlas by joint modelling of multiple slices with deep neural networks

G Wang, J Zhao, Y Yan, Y Wang, AR Wu… - Nature Machine …, 2023 - nature.com
Spatial transcriptomics (ST) technologies are revolutionizing the way to explore the spatial
architecture of tissues. Currently, ST data analysis is often restricted to a single two …

Gene expression cartography

M Nitzan, N Karaiskos, N Friedman, N Rajewsky - Nature, 2019 - nature.com
Multiplexed RNA sequencing in individual cells is transforming basic and clinical life
sciences,,–. Often, however, tissues must first be dissociated, and crucial information about …

High-resolution 3D spatiotemporal transcriptomic maps of develo** Drosophila embryos and larvae

M Wang, Q Hu, T Lv, Y Wang, Q Lan, R **ang, Z Tu… - Developmental Cell, 2022 - cell.com
Drosophila has long been a successful model organism in multiple biomedical fields. Spatial
gene expression patterns are critical for the understanding of complex pathways and …

Ultrasensitive proteome analysis using paramagnetic bead technology

CS Hughes, S Foehr, DA Garfield… - Molecular systems …, 2014 - embopress.org
In order to obtain a systems‐level understanding of a complex biological system, detailed
proteome information is essential. Despite great progress in proteomics technologies …

Germline Cas9 promoters with improved performance for homing gene drive

J Du, W Chen, X Jia, X Xu, E Yang, R Zhou… - Nature …, 2024 - nature.com
Gene drive systems could be a viable strategy to prevent pathogen transmission or suppress
vector populations by propagating drive alleles with super-Mendelian inheritance. CRISPR …