Chromosomal fragile sites are specific loci that preferentially exhibit gaps and breaks on
metaphase chromosomes following partial inhibition of DNA synthesis. Their discovery has …

The common fragile sites are large regions of genomic instability that are found in all
individuals and are hot spots for chromosomal rearrangements and deletions. A number of …

Gastric cancer is one of the most prevalent and aggressive cancers worldwide, and its
molecular mechanism remains largely elusive. Here we report the genomic landscape in …

The Fra3B locus on chromosome 3p14. 2 targeting the fragile histidine triad (Fhit) gene
represents one of the most common fragile sites of the human genome and is associated …

The Fhit tumor suppressor binds and hydrolyses diadenosine polyphosphates and the Fhit–
substrate complex has been proposed as a proapoptotic effector, as determined by infection …

It was hypothesized as early as 1986, that the recently discovered common fragile sites
could facilitate recombination events, such as deletions and translocations, that result in …

Loss or attenuated expression of the tumor-suppressor gene FHIT is associated
paradoxically with poor progression of human tumors. Fhit promotes apoptosis and …

In many cancers, including lung carcinomas, Fragile histidine triad (Fhit) is frequently
decreased or lost. Fhit status has recently been shown to be associated with elevated in vitro …

Abstract The Arabidopsis (Arabidopsis thaliana) constitutive triple response1-10 (ctr1-10)
mutant produces a reduced level of CTR1 protein and exhibits a weak ctr1 mutant …

Quantum size effects are becoming increasingly important in microelectronics, as the
dimensions of the structures shrink laterally towards 100 nm and vertically towards 10 nm …