Feeding, which is essential for all animals, is regulated by homeostatic mechanisms. In
addition, food consumption is temporally coordinated by the brain over the circadian (~ 24 h) …

The mammalian circadian system, which is comprised of multiple cellular clocks located in
the organs and tissues, orchestrates their regulation in a hierarchical manner throughout the …

Most physiology and behavior of mammalian organisms follow daily oscillations. These
rhythmic processes are governed by environmental cues (eg, fluctuations in light intensity …

Daily rhythms in physiology significantly modulate drug pharmacokinetics and
pharmacodynamics according to the time-of-day, a finding that has led to the concept of …

Accumulating evidence highlights intriguing interplays between circadian and metabolic
pathways. We show that PER2 directly and specifically represses PPARγ, a nuclear receptor …

The circadian system orchestrates the temporal organization of many aspects of physiology,
including metabolism, in synchrony with the 24 hr rotation of the Earth. Like the metabolic …

The circadian clock is a molecular and cellular oscillator found in most mammalian tissues
that regulates rhythmic physiology and behavior. Numerous investigations have addressed …

Obesity has become a serious public health problem and a major risk factor for the
development of illnesses, such as insulin resistance and hypertension. Human homeostatic …

Glucocorticoids, hormones produced by the adrenal gland cortex, exert numerous functions
in body homeostasis and the response of the organism to external stressors. One striking …

Time-restricted eating (TRE) is a dietary intervention that limits food consumption to a
specific time window each day. The effect of TRE on body weight and physiological …