HIV-1 vaccines based on antibody identification, B cell ontogeny, and epitope structure
PD Kwong, JR Mascola - Immunity, 2018 - cell.com
HIV-1 vaccine development has been stymied by an inability to induce broadly reactive
neutralizing antibodies to the envelope (Env) trimer, the sole viral antigen on the virion …
neutralizing antibodies to the envelope (Env) trimer, the sole viral antigen on the virion …
Antibody responses to viral infections: a structural perspective across three different enveloped viruses
CD Murin, IA Wilson, AB Ward - Nature microbiology, 2019 - nature.com
Antibodies serve as critical barriers to viral infection. Humoral immunity to a virus is achieved
through the dual role of antibodies in communicating the presence of invading pathogens in …
through the dual role of antibodies in communicating the presence of invading pathogens in …
Controlling the SARS-CoV-2 spike glycoprotein conformation
The coronavirus (CoV) spike (S) protein, involved in viral–host cell fusion, is the primary
immunogenic target for virus neutralization and the current focus of many vaccine design …
immunogenic target for virus neutralization and the current focus of many vaccine design …
A multiclade env–gag VLP mRNA vaccine elicits tier-2 HIV-1-neutralizing antibodies and reduces the risk of heterologous SHIV infection in macaques
The development of a protective vaccine remains a top priority for the control of the HIV/AIDS
pandemic. Here, we show that a messenger RNA (mRNA) vaccine co-expressing …
pandemic. Here, we show that a messenger RNA (mRNA) vaccine co-expressing …
[HTML][HTML] Slow delivery immunization enhances HIV neutralizing antibody and germinal center responses via modulation of immunodominance
KM Cirelli, DG Carnathan, B Nogal, JT Martin… - Cell, 2019 - cell.com
Conventional immunization strategies will likely be insufficient for the development of a
broadly neutralizing antibody (bnAb) vaccine for HIV or other difficult pathogens because of …
broadly neutralizing antibody (bnAb) vaccine for HIV or other difficult pathogens because of …
Safety and tolerability of AAV8 delivery of a broadly neutralizing antibody in adults living with HIV: a phase 1, dose-escalation trial
JP Casazza, EM Cale, S Narpala, GV Yamshchikov… - Nature medicine, 2022 - nature.com
Adeno-associated viral vector-mediated transfer of DNA coding for broadly neutralizing anti-
HIV antibodies (bnAbs) offers an alternative to attempting to induce protection by vaccination …
HIV antibodies (bnAbs) offers an alternative to attempting to induce protection by vaccination …
Enhancing and sha** the immunogenicity of native-like HIV-1 envelope trimers with a two-component protein nanoparticle
The development of native-like HIV-1 envelope (Env) trimer antigens has enabled the
induction of neutralizing antibody (NAb) responses against neutralization-resistant HIV-1 …
induction of neutralizing antibody (NAb) responses against neutralization-resistant HIV-1 …
Common features of enveloped viruses and implications for immunogen design for next-generation vaccines
FA Rey, SM Lok - Cell, 2018 - cell.com
Enveloped viruses enter cells by inducing fusion of viral and cellular membranes, a process
catalyzed by a specialized membrane-fusion protein expressed on their surface. This review …
catalyzed by a specialized membrane-fusion protein expressed on their surface. This review …
Tailored design of protein nanoparticle scaffolds for multivalent presentation of viral glycoprotein antigens
Multivalent presentation of viral glycoproteins can substantially increase the elicitation of
antigen-specific antibodies. To enable a new generation of anti-viral vaccines, we designed …
antigen-specific antibodies. To enable a new generation of anti-viral vaccines, we designed …
Advances in hydrogen/deuterium exchange mass spectrometry and the pursuit of challenging biological systems
Solution-phase hydrogen/deuterium exchange (HDX) coupled to mass spectrometry (MS) is
a widespread tool for structural analysis across academia and the biopharmaceutical …
a widespread tool for structural analysis across academia and the biopharmaceutical …