CYP2E1 in alcoholic and non-alcoholic liver injury. Roles of ROS, reactive intermediates and lipid overload
R Harjumäki, CS Pridgeon… - International Journal of …, 2021 - mdpi.com
CYP2E1 is one of the fifty-seven cytochrome P450 genes in the human genome and is
highly conserved. CYP2E1 is a unique P450 enzyme because its heme iron is constitutively …
highly conserved. CYP2E1 is a unique P450 enzyme because its heme iron is constitutively …
SGLT-2 inhibitors in NAFLD: expanding their role beyond diabetes and cardioprotection
Non-alcoholic fatty liver disease (NAFLD) is an 'umbrella'term, comprising a spectrum
ranging from benign, liver steatosis to non-alcoholic steatohepatitis, liver fibrosis and …
ranging from benign, liver steatosis to non-alcoholic steatohepatitis, liver fibrosis and …
Genetic and diet-induced animal models for non-alcoholic fatty liver disease (NAFLD) research
CM Flessa, N Nasiri-Ansari, I Kyrou, BM Leca… - International Journal of …, 2022 - mdpi.com
A rapidly increasing incidence of non-alcoholic fatty liver disease (NAFLD) is noted
worldwide due to the adoption of western-type lifestyles and eating habits. This makes the …
worldwide due to the adoption of western-type lifestyles and eating habits. This makes the …
The influence of sex hormones in liver function and disease
The liver performs a multitude of bodily functions, whilst retaining the ability to regenerate
damaged tissue. In this review, we discuss sex steroid biology, regulation of mammalian …
damaged tissue. In this review, we discuss sex steroid biology, regulation of mammalian …
In vitro models for non-alcoholic fatty liver disease: Emerging platforms and their applications
MJ Ramos, L Bandiera, F Menolascina, JA Fallowfield - Iscience, 2022 - cell.com
Non-alcoholic fatty liver disease (NAFLD) represents a global healthcare challenge,
affecting 1 in 4 adults, and death rates are predicted to rise inexorably. The progressive form …
affecting 1 in 4 adults, and death rates are predicted to rise inexorably. The progressive form …
Reverse pharmacology of Nimbin-N2 attenuates alcoholic liver injury and promotes the hepatoprotective dual role of improving lipid metabolism and downregulating …
G Sudhakaran, P Prathap, A Guru… - Molecular and cellular …, 2022 - Springer
Alcoholic liver disease is one of the most prominent liver diseases in the world. Lipid
accumulation accompanied by oxidative stress and inflammation in the liver is the most …
accumulation accompanied by oxidative stress and inflammation in the liver is the most …
Human liver cancer organoids: Biological applications, current challenges, and prospects in hepatoma therapy
L Chen, X Wei, D Gu, Y Xu, H Zhou - Cancer Letters, 2023 - Elsevier
Liver cancer and disease are among the most socially challenging global health concerns.
Although organ transplantation, surgical resection and anticancer drugs are the main …
Although organ transplantation, surgical resection and anticancer drugs are the main …
Microfluidic organ-on-a-chip devices for liver disease modeling in vitro
P Kanabekova, A Kadyrova, G Kulsharova - Micromachines, 2022 - mdpi.com
Mortality from liver disease conditions continues to be very high. As liver diseases manifest
and progress silently, prompt measures after diagnosis are essential in the treatment of …
and progress silently, prompt measures after diagnosis are essential in the treatment of …
Gut–Liver axis and non-alcoholic fatty liver disease: A vicious circle of dysfunctions orchestrated by the gut microbiome
S Pezzino, M Sofia, G Faletra, C Mazzone, G Litrico… - Biology, 2022 - mdpi.com
Simple Summary Non-alcoholic fatty liver disease (NAFLD) is a widespread disease
associated with metabolic disorders, such as obesity. In recent years, there has been …
associated with metabolic disorders, such as obesity. In recent years, there has been …
Organotypic and microphysiological human tissue models for drug discovery and development—current state-of-the-art and future perspectives
The number of successful drug development projects has been stagnant for decades
despite major breakthroughs in chemistry, molecular biology, and genetics. Unreliable target …
despite major breakthroughs in chemistry, molecular biology, and genetics. Unreliable target …