Ovarian cancer remains the most lethal gynaecological malignancy with 314 000 cases and
207 000 deaths annually worldwide. Ovarian cancer cases and deaths are predicted to …

Recent advances in human genomics and the advent of molecular medicine have
catapulted our ability to characterize human and health and disease. Scientists and …

Three inherited autosomal dominant conditions—BRCA-related hereditary breast and
ovarian cancer (HBOC), Lynch syndrome (LS) and familial hypercholesterolemia (FH) …

Background: The cost-effectiveness of screening the US population for Centers for Disease
Control and Prevention (CDC) Tier 1 genomic conditions is unknown. Objective: To estimate …

Increased demand for in vitro fertilization (IVF) due to socio-demographic trends, and supply
facilitated by new technologies, converged to transform the way a substantial proportion of …

Purpose Three genetic conditions—hereditary breast and ovarian cancer syndrome, Lynch
syndrome, and familial hypercholesterolemia—have tier 1 evidence for interventions that …

Over 100 million research participants around the world have had research array-based
genoty** (GT) or genome sequencing (GS), but only a small fraction of these have been …

Importance Pathogenic DNA variants associated with familial hypercholesterolemia,
hereditary breast and ovarian cancer syndrome, and Lynch syndrome are widely recognized …

Importance Genomic screening for hereditary breast and ovarian cancer (HBOC) in
unselected women offers an opportunity to prevent cancer morbidity and mortality, but the …

Importance Population screening for medically relevant genomic variants that cause
diseases such as hereditary cancer and cardiovascular disorders is increasing to facilitate …