Ecology and evolution of Mycobacterium tuberculosis

S Gagneux - Nature Reviews Microbiology, 2018 - nature.com
Tuberculosis (TB) is the number one cause of human death due to an infectious disease.
The causative agents of TB are a group of closely related bacteria known as the …

Towards a genomics-informed, real-time, global pathogen surveillance system

JL Gardy, NJ Loman - Nature Reviews Genetics, 2018 - nature.com
Abstract The recent Ebola and Zika epidemics demonstrate the need for the continuous
surveillance, rapid diagnosis and real-time tracking of emerging infectious diseases. Fast …

[HTML][HTML] Elevated rates of horizontal gene transfer in the industrialized human microbiome

M Groussin, M Poyet, A Sistiaga, SM Kearney, K Moniz… - Cell, 2021 - cell.com
Industrialization has impacted the human gut ecosystem, resulting in altered microbiome
composition and diversity. Whether bacterial genomes may also adapt to the …

[HTML][HTML] Reconstruction of ancient microbial genomes from the human gut

MC Wibowo, Z Yang, M Borry, A Hübner, KD Huang… - Nature, 2021 - nature.com
Loss of gut microbial diversity,,,,–in industrial populations is associated with chronic
diseases, underscoring the importance of studying our ancestral gut microbiome. However …

Global diversity and antimicrobial resistance of typhoid fever pathogens: Insights from a meta-analysis of 13,000 Salmonella Typhi genomes

ME Carey, ZA Dyson, DJ Ingle, A Amir, MK Aworh… - Elife, 2023 - elifesciences.org
Background: The Global Typhoid Genomics Consortium was established to bring together
the typhoid research community to aggregate and analyse Salmonella enterica serovar …

Gastrointestinal Carriage Is a Major Reservoir of Klebsiella pneumoniae Infection in Intensive Care Patients

CL Gorrie, M Mirčeta, RR Wick… - Clinical infectious …, 2017 - academic.oup.com
Background. Klebsiella pneumoniae is an opportunistic pathogen and leading cause of
hospital-associated infections. Intensive care unit (ICU) patients are particularly at risk …

Ancient pathogen genomics as an emerging tool for infectious disease research

MA Spyrou, KI Bos, A Herbig, J Krause - Nature Reviews Genetics, 2019 - nature.com
Over the past decade, a genomics revolution, made possible through the development of
high-throughput sequencing, has triggered considerable progress in the study of ancient …

The distribution of bacterial doubling times in the wild

B Gibson, DJ Wilson, E Feil… - Proceedings of the …, 2018 - royalsocietypublishing.org
Generation time varies widely across organisms and is an important factor in the life cycle,
life history and evolution of organisms. Although the doubling time (DT) has been estimated …

Widespread extinctions of co-diversified primate gut bacterial symbionts from humans

JG Sanders, DD Sprockett, Y Li, D Mjungu… - Nature …, 2023 - nature.com
Humans and other primates harbour complex gut bacterial communities that influence
health and disease, but the evolutionary histories of these symbioses remain unclear. This is …

Genomic history of the seventh pandemic of cholera in Africa

FX Weill, D Domman, E Njamkepo, C Tarr, J Rauzier… - Science, 2017 - science.org
The seventh cholera pandemic has heavily affected Africa, although the origin and
continental spread of the disease remain undefined. We used genomic data from 1070 …