Diabetes mellitus is a metabolic disorder that affects more than 460 million people
worldwide. Type 1 diabetes (T1D) is caused by autoimmune destruction of β-cells, whereas …

A wealth of data and comprehensive reviews exist on pancreas development in mammals,
primarily mice, and other vertebrates. By contrast, human pancreatic development has been …

Type 2 diabetes affects over 300 million people, causing severe complications and
premature death, yet the underlying molecular mechanisms are largely unknown. Pancreatic …

Pancreas oganogenesis comprises a coordinated and highly complex interplay of signaling
events and transcriptional networks that guide a step‐wise process of organ development …

In the mammalian pancreas, the endocrine cell types of the islets of Langerhans, including
the α-, β-, δ-, and pancreatic polypeptide cells as well as the exocrine cells, derive from …

Most pancreatic neuroendocrine tumors (PNETs) do not produce excess hormones and are
therefore considered 'non-functional',–. As clinical behaviors vary widely and distant …

Understanding the biology underlying the mechanisms and pathways regulating pancreatic
β cell development is necessary to understand the pathology of diabetes mellitus (DM) …

Knowledge of human pancreas development underpins our interpretation and exploitation
of human pluripotent stem cell (PSC) differentiation toward a β-cell fate. However, almost no …

Abstract Development of endocrine cells in the endoderm involves Atonal and
Achaete/Scute-related basic helix-loop-helix (bHLH) proteins. These proteins also serve as …

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