Biological, physiological, pathophysiological, and pharmacological aspects of ghrelin

AJ Van Der Lely, M Tschop, ML Heiman… - Endocrine …, 2004 - academic.oup.com
Ghrelin is a peptide predominantly produced by the stomach. Ghrelin displays strong GH-
releasing activity. This activity is mediated by the activation of the so-called GH …

Ghrelin—a hormone with multiple functions

M Korbonits, AP Goldstone, M Gueorguiev… - Frontiers in …, 2004 - Elsevier
Ghrelin is brain-gut peptide with growth hormone-releasing and appetite-inducing activities.
It is mainly secreted from the stomach mucosa but it is also expressed widely in different …

Ghrelin and des-acyl ghrelin inhibit cell death in cardiomyocytes and endothelial cells through ERK1/2 and PI 3-kinase/AKT

G Baldanzi, N Filigheddu, S Cutrupi… - The Journal of cell …, 2002 - rupress.org
Ghrelin is an acyl-peptide gastric hormone acting on the pituitary and hypothalamus to
stimulate growth hormone (GH) release, adiposity, and appetite. Ghrelin endocrine activities …

Ghrelin, appetite, and gastric motility: the emerging role of the stomach as an endocrine organ

A Inui, A Asakawa, C Y. Bowers… - The FASEB …, 2004 - Wiley Online Library
Recent progress in the field of energy homeostasis was triggered by the discovery of
adipocyte hormone leptin and revealed a complex regulatory neuroendocrine network. A …

Ghrelin increases energy intake in cancer patients with impaired appetite: acute, randomized, placebo-controlled trial

NM Neary, CJ Small, AM Wren, JL Lee… - The Journal of …, 2004 - academic.oup.com
There is a pressing need for more effective appetite-stimulatory therapies for many patient
groups including those with cancer. We have previously demonstrated that the gastric …

Ghrelin in the regulation of body weight and metabolism

TR Castaneda, J Tong, R Datta, M Culler… - Frontiers in …, 2010 - Elsevier
Ghrelin, a peptide hormone predominantly produced by the stomach, was isolated as the
endogenous ligand for the growth hormone secretagogue receptor. Ghrelin is a potent …

Exercise-induced suppression of acylated ghrelin in humans

DR Broom, DJ Stensel, NC Bishop… - Journal of applied …, 2007 - journals.physiology.org
Ghrelin is an orexigenic hormone secreted from endocrine cells in the stomach and other
tissues. Acylation of ghrelin is essential for appetite regulation. Vigorous exercise induces …

Ghrelin and Des-Octanoyl Ghrelin Promote Adipogenesis Directly in Vivo by a Mechanism Independent of the Type 1a Growth Hormone Secretagogue Receptor

NM Thompson, DAS Gill, R Davies, N Loveridge… - …, 2004 - academic.oup.com
Ghrelin promotes fat accumulation, despite potent stimulation of the lipolytic hormone, GH.
The function of the major circulating isoform of ghrelin, des-octanoyl ghrelin, is unclear …

Neuroendocrine and peripheral activities of ghrelin: implications in metabolism and obesity

G Muccioli, M Tschöp, M Papotti, R Deghenghi… - European journal of …, 2002 - Elsevier
Ghrelin, a 28-amino acid acylated peptide predominantly produced by the stomach, displays
strong growth hormone (GH)-releasing activity mediated by the hypothalamus–pituitary GH …

Expression of ghrelin and of the GH secretagogue receptor by pancreatic islet cells and related endocrine tumors

M Volante, E AllÌa, P Gugliotta, A Funaro… - The Journal of …, 2002 - academic.oup.com
Ghrelin is a novel gastrointestinal hormone produced by rat and human gastric X-like
neuroendocrine cells, which strongly stimulates GH secretion and influences energy …