[HTML][HTML] Metabolic drivers of non-alcoholic fatty liver disease
Background The incidence of non-alcoholic fatty liver disease (NAFLD) is rapidly increasing
worldwide parallel to the global obesity epidemic. NAFLD encompasses a range of liver …
worldwide parallel to the global obesity epidemic. NAFLD encompasses a range of liver …
[HTML][HTML] Genetic and epigenetic factors determining NAFLD risk
W Jonas, A Schürmann - Molecular metabolism, 2021 - Elsevier
Background Hepatic steatosis is a common chronic liver disease that can progress into more
severe stages of NAFLD or promote the development of life-threatening secondary diseases …
severe stages of NAFLD or promote the development of life-threatening secondary diseases …
[HTML][HTML] Genome-wide association study of non-alcoholic fatty liver and steatohepatitis in a histologically characterised cohort☆
Background & Aims Genetic factors associated with non-alcoholic fatty liver disease
(NAFLD) remain incompletely understood. To date, most genome-wide association studies …
(NAFLD) remain incompletely understood. To date, most genome-wide association studies …
Association of genetic variation with cirrhosis: a multi-trait genome-wide association and gene–environment interaction study
Background & Aims In contrast to most other common diseases, few genetic variants have
been identified that impact risk of cirrhosis. We aimed to identify new genetic variants that …
been identified that impact risk of cirrhosis. We aimed to identify new genetic variants that …
[HTML][HTML] rs641738C> T near MBOAT7 is associated with liver fat, ALT and fibrosis in NAFLD: A meta-analysis
K Teo, KWM Abeysekera, L Adams, E Aigner… - Journal of …, 2021 - Elsevier
Background & Aims A common genetic variant near MBOAT7 (rs641738C> T) has been
previously associated with hepatic fat and advanced histology in NAFLD; however, these …
previously associated with hepatic fat and advanced histology in NAFLD; however, these …
The role of omics in the pathophysiology, diagnosis and treatment of non-alcoholic fatty liver disease
Non-alcoholic fatty liver disease (NAFLD) is a multifaceted metabolic disorder, whose
spectrum covers clinical, histological and pathophysiological developments ranging from …
spectrum covers clinical, histological and pathophysiological developments ranging from …
Diagnostic modalities of non-alcoholic fatty liver disease: from biochemical biomarkers to multi-omics non-invasive approaches
E Martinou, M Pericleous, I Stefanova, V Kaur… - Diagnostics, 2022 - mdpi.com
Non-Alcoholic Fatty Liver Disease (NAFLD) is currently the most common cause of chronic
liver disease worldwide, and its prevalence is increasing globally. NAFLD is a multifaceted …
liver disease worldwide, and its prevalence is increasing globally. NAFLD is a multifaceted …
MBOAT7 in liver and extrahepatic diseases
MBOAT7 is a protein anchored to endomembranes by several transmembrane domains. It
has a catalytic dyad involved in remodelling of phosphatidylinositol with polyunsaturated …
has a catalytic dyad involved in remodelling of phosphatidylinositol with polyunsaturated …
Genetics is of the essence to face NAFLD
Nonalcoholic fatty liver disease (NAFLD) is the commonest cause of chronic liver disease
worldwide. It is closely related to obesity, insulin resistance (IR) and dyslipidemia so much …
worldwide. It is closely related to obesity, insulin resistance (IR) and dyslipidemia so much …
The role of PNPLA3 in health and disease
The human patatin-like phospholipase domain-containing 3 (PNPLA3) gene encodes for a
protein of 481 amino-acids. The variant rs738409 is a cytosine to guanine substitution …
protein of 481 amino-acids. The variant rs738409 is a cytosine to guanine substitution …