Schizophrenia and influenza at the centenary of the 1918-1919 Spanish influenza pandemic: mechanisms of psychosis risk
Associations between influenza infection and psychosis have been reported since the
eighteenth century, with acute “psychoses of influenza” documented during multiple …
eighteenth century, with acute “psychoses of influenza” documented during multiple …
Pleiotropy and cross-disorder genetics among psychiatric disorders
Genome-wide analyses of common and rare genetic variations have documented the
heritability of major psychiatric disorders, established their highly polygenic genetic …
heritability of major psychiatric disorders, established their highly polygenic genetic …
Shared heritability of human face and brain shape
Evidence from model organisms and clinical genetics suggests coordination between the
develo** brain and face, but the role of this link in common genetic variation remains …
develo** brain and face, but the role of this link in common genetic variation remains …
[PDF][PDF] Psoriasis and genetics
Theme issue: Psoriasis loci. Despite the complex correlation structure across the MHC due
to extensive linkage disequilibrium (Box 1)(16), HLA-C* 06: 02 is now confidently …
to extensive linkage disequilibrium (Box 1)(16), HLA-C* 06: 02 is now confidently …
Effect of polygenic risk for schizophrenia on cardiac structure and function: a UK Biobank observational study
Background Cardiovascular disease is a major cause of excess mortality in people with
schizophrenia. Several factors are responsible, including lifestyle and metabolic effects of …
schizophrenia. Several factors are responsible, including lifestyle and metabolic effects of …
Role of the gut-brain axis in the shared genetic etiology between gastrointestinal tract diseases and psychiatric disorders: A genome-wide pleiotropic analysis
Importance Comorbidities and genetic correlations between gastrointestinal tract diseases
and psychiatric disorders have been widely reported, with the gut-brain axis (GBA) …
and psychiatric disorders have been widely reported, with the gut-brain axis (GBA) …
Genetic variants associated with psychiatric disorders are enriched at epigenetically active sites in lymphoid cells
ME Lynall, B Soskic, J Hayhurst… - Nature …, 2022 - nature.com
Multiple psychiatric disorders have been associated with abnormalities in both the innate
and adaptive immune systems. The role of these abnormalities in pathogenesis, and …
and adaptive immune systems. The role of these abnormalities in pathogenesis, and …
An atlas of genetic correlations and genetically informed associations linking psychiatric and immune-related phenotypes
Importance Certain psychiatric and immune-related disorders are reciprocal risk factors.
However, the nature of these associations is unclear. Objective To characterize the …
However, the nature of these associations is unclear. Objective To characterize the …
Genetic map** across autoimmune diseases reveals shared associations and mechanisms
MR Lincoln, N Connally, PP Axisa, C Gasperi… - Nature Genetics, 2024 - nature.com
Autoimmune and inflammatory diseases are polygenic disorders of the immune system.
Many genomic loci harbor risk alleles for several diseases, but the limited resolution of …
Many genomic loci harbor risk alleles for several diseases, but the limited resolution of …
Innate immunity: a common denominator between neurodegenerative and neuropsychiatric diseases
The intricate relationships between innate immunity and brain diseases raise increased
interest across the wide spectrum of neurodegenerative and neuropsychiatric disorders …
interest across the wide spectrum of neurodegenerative and neuropsychiatric disorders …