Capillary forces generated by biomolecular condensates

B Gouveia, Y Kim, JW Shaevitz, S Petry, HA Stone… - Nature, 2022 - nature.com
Liquid–liquid phase separation and related phase transitions have emerged as generic
mechanisms in living cells for the formation of membraneless compartments or biomolecular …

Engineering synthetic biomolecular condensates

Y Dai, L You, A Chilkoti - Nature Reviews Bioengineering, 2023 - nature.com
The concept of phase-separation-mediated formation of biomolecular condensates provides
a new framework to understand cellular organization and cooperativity-dependent cellular …

Phase separation of protein mixtures is driven by the interplay of homotypic and heterotypic interactions

M Farag, WM Borcherds, A Bremer, T Mittag… - Nature …, 2023 - nature.com
Prion-like low-complexity domains (PLCDs) are involved in the formation and regulation of
distinct biomolecular condensates that form via phase separation coupled to percolation …

Molecular and environmental determinants of biomolecular condensate formation

JA Villegas, M Heidenreich, ED Levy - Nature chemical biology, 2022 - nature.com
Biomolecular condensate formation has been implicated in a host of biological processes
and has found relevance in biology and disease. Understanding the physical principles and …

The interface of condensates of the hnRNPA1 low-complexity domain promotes formation of amyloid fibrils

M Linsenmeier, L Faltova, C Morelli… - Nature …, 2023 - nature.com
The maturation of liquid-like protein condensates into amyloid fibrils has been associated
with several neurodegenerative diseases. However, the molecular mechanisms underlying …

Principles governing the phase separation of multidomain proteins

P Mohanty, U Kapoor… - Biochemistry, 2022 - ACS Publications
A variety of membraneless organelles, often termed “biological condensates”, play an
important role in the regulation of cellular processes such as gene transcription, translation …

Multivalent interactions between molecular components involved in fast endophilin mediated endocytosis drive protein phase separation

S Mondal, K Narayan, S Botterbusch, I Powers… - Nature …, 2022 - nature.com
A specific group of transmembrane receptors, including the β1-adrenergic receptor (β1-AR),
is internalized through a non-clathrin pathway known as Fast Endophilin Mediated …