ALOX12 encodes arachidonic acid 12-lipoxygenase that acts on different polyunsaturated
fatty acid substrates to produce biologically active lipid mediators including eicosanes and …

Stromal cells are a subject of rapidly growing immunological interest based on their ability to
influence virtually all aspects of innate and adaptive immunity. Present in every bodily tissue …

The molecular bases of how host genetic variation impacts the gut microbiome remain
largely unknown. Here we used a genetically diverse mouse population and applied …

Background The cross-talk between the host and its microbiota plays a key role in the
promotion of health. The production of metabolites such as polyamines by intestinal-resident …

The commensal bacteria that make up the gut microbiota impact the health of their host on
multiple levels. In particular, the interactions taking place between the microbe-associated …

The Hedgehog (HH) signaling pathway plays important roles in gastrointestinal
carcinogenesis and the gastrointestinal tumor microenvironment (TME). Aberrant HH …

Arctigenin, the major active constituent of Fructus Arctii, has been reported to inhibit the
growth of various tumors and alleviate colitis. This study aimed to prove the protective effect …

Guillain–Barré syndrome (GBS), an immune-mediated disorder affecting the peripheral
nervous system, is the most common and severe acute paralytic neuropathy. GBS remains …

Chronic inflammation induced by Helicobacter pylori infection is a critical factor in the
development of peptic ulcer disease and gastric cancer. Central to this inflammation is the …

Background Various regions of the chicken genome have been under natural and artificial
selection for thousands of years. The substantial diversity that exits among chickens from …