Virtually, all tumor cells as well as all immune cells express plasma membrane receptors for
extracellular nucleosides (adenosine) and nucleotides (ATP, ADP, UTP, UDP and sugar …

Under physiological conditions, adenosine triphosphate (ATP) is present at low levels in the
extracellular milieu, being massively released by stressed or dying cells. Once outside the …

Damage associated molecular patterns (DAMPs) are intracellular molecules released from
infected or injured cells to activate inflammatory and reparatory responses. One of the most …

Background & Aims The severity of sepsis can be linked to excessive inflammatory
responses resulting in hepatic injury. P2X7 receptor activation by extracellular ATP (eATP) …

A polymorphism in the P2RX7 gene that encodes for the P2X7 ionotropic ATP-gated
receptor (P2X7R) protein has been shown to be associated with an increased risk for …

P2X7 receptor is an ion channel activated by extracellular adenosine trisphosphate (eATP)
that attracted increasing attention for its role in immune reactions, neurobiology and …

P2X7 purinergic receptor (P2X7R) has been implicated in several cardiovascular diseases.
However, whether it regulates cardiac fibrosis remains elusive. Herein, its involvement in the …

Liver fibrosis is a dynamic reversible pathological process in the development of chronic
liver disease to cirrhosis. However, the current treatments are not administered for a long …

The World Health Organization has estimated that approximately 3 million deaths are
attributable to alcohol consumption each year. Alcohol consumption is notably associated …

Background/Aims: Changes in cell-to-cell communication have been linked to several
secondary complications of diabetes, but the mechanism by which connexins affect disease …