Reflected cross-polarized light microscopy as a method for measuring collagen fiber crimp in musculoskeletal tissues
Many musculoskeletal tissues are composed primarily of type I collagen, which takes on a
periodic crimp morphology that allows large tensile strains in the tissue. The spatial period of …
periodic crimp morphology that allows large tensile strains in the tissue. The spatial period of …
Slow depressurization following intradiscal injection leads to injectate leakage in a large animal model
Needle injection has been indicated as the most practical method of delivering therapeutic
agents to the intervertebral disc due to the disc's largely avascular nature. As the disc is …
agents to the intervertebral disc due to the disc's largely avascular nature. As the disc is …
[HTML][HTML] A novel in-vitro model of intervertebral disc degeneration using hyperphysiological loading
Intervertebral disc (IVD) degeneration includes changes in tissue biomechanics, physical
attributes, biochemical composition, disc microstructure, and cellularity, which can all affect …
attributes, biochemical composition, disc microstructure, and cellularity, which can all affect …
Establishing a through-puncture model for assessing post-injection leakage in the intervertebral disc
Purpose Needle injection through the outer annulus fibrosus of the intervertebral disc (IVD)
is the most practical approach for delivery of therapeutic agents, which have been shown to …
is the most practical approach for delivery of therapeutic agents, which have been shown to …
Three‐dimensional fiber patterning in the annulus fibrosus can be derived from vertebral endplate topography
Introduction The annulus fibrosus (AF) of the Intervertebral disc (IVD) is composed of
concentric lamellae of helically wound collagen fibers. Understanding the spatial variation of …
concentric lamellae of helically wound collagen fibers. Understanding the spatial variation of …
Enzymatic Digestion of the Intervertebral Disc Alters Intradiscal Injection and Leakage Mechanics
Z Appel, AJ Michalek - Journal of Biomechanical …, 2024 - asmedigitalcollection.asme.org
Intradiscal injection is required to deliver therapeutic agents to the intervertebral disc (IVD)
nucleus pulposus (NP). However, injectate leakage following needle retraction may result in …
nucleus pulposus (NP). However, injectate leakage following needle retraction may result in …
A novel in-vitro model of intervertebral disc degeneration using hyperphysiological loading.
Intervertebral disc (IVD) degeneration includes changes in tissue biomechanics, physical
attributes, biochemical composition, disc microstructure, and cellularity, which can all affect …
attributes, biochemical composition, disc microstructure, and cellularity, which can all affect …