Antipsychotic drugs are central to the treatment of schizophrenia and other psychotic
disorders but are ineffective for some patients and associated with side-effects and …

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Elevated dopamine transmission in psychosis is assumed to unbalance striatal output
through D1-and D2-receptor-expressing spiny-projection neurons (SPNs). Antipsychotic …

Schizophrenia is a chronic and debilitating neuropsychiatric disorder affecting
approximately 1% of the world's population. This disease is associated with considerable …

Since the introduction of chlorpromazine and throughout the development of the new-
generation antipsychotic drugs (APDs) beginning with clozapine, the D 2 receptor has been …

Since the 1970s, clinicians have increasingly become more familiar with hyperprolactinemia
(HPRL) as a common adverse effect of antipsychotic medication, which remains the …

OBJECTIVE: Since all antipsychotics block dopamine D2 receptors, the authors investigated
how well D2 receptor occupancy in vivo predicts clinical response, extrapyramidal side …

The treatment of schizophrenia has evolved over the past half century primarily in the
context of antipsychotic drug development. Although there has been significant progress …

Background: Al though the prin ci pal brain tar get that all an tipsy chotic drugs at tach to is
the do pamine D2 re cep tor, tra di tional or typi cal an tipsy chot ics, by at tach ing to it, in …

Summary Background The polymorphic CYP2D6 enzyme metabolises the antipsychotic
drugs risperidone and aripiprazole to their active metabolites, 9OH-risperidone and …