From menopause to neurodegeneration—molecular basis and potential therapy
The impacts of menopause on neurodegenerative diseases, especially the changes in
steroid hormones, have been well described in cell models, animal models, and humans …
steroid hormones, have been well described in cell models, animal models, and humans …
The role of glycogen synthase kinase 3 beta in neurodegenerative diseases
H Yu, M **ong, Z Zhang - Frontiers in Molecular Neuroscience, 2023 - frontiersin.org
Neurodegenerative diseases (NDDs) pose an increasingly prevalent threat to the well-being
and survival of elderly individuals worldwide. NDDs include Alzheimer's disease (AD) …
and survival of elderly individuals worldwide. NDDs include Alzheimer's disease (AD) …
Regulation of the Late Onset alzheimer's Disease Associated HLA-DQA1/DRB1 Expression
(Genome-wide Association Studies) GWAS have identified∼ 42 late-onset Alzheimer's
disease (LOAD)-associated loci, each of which contains multiple single nucleotide …
disease (LOAD)-associated loci, each of which contains multiple single nucleotide …
Role of microRNA-502-3p in human diseases
MicroRNAs (miRNAs) are non-coding RNAs that play a major role in gene regulation in
several diseases. MicroRNA-502-3p (MiR-502-3p) has been previously characterized in a …
several diseases. MicroRNA-502-3p (MiR-502-3p) has been previously characterized in a …
The potential benefits of nanotechnology in treating Alzheimer's disease
TS Ling, S Chandrasegaran, LZ Xuan… - BioMed research …, 2021 - Wiley Online Library
Alzheimer's disease is a neurodegenerative disorder that is caused by the accumulation of
beta‐amyloid plaques in the brain. Currently, there is no definitive cure available to treat …
beta‐amyloid plaques in the brain. Currently, there is no definitive cure available to treat …
ApoER2-Dab1 disruption as the origin of pTau-associated neurodegeneration in sporadic Alzheimer's disease
In sporadic Alzheimer's disease (sAD) specific regions, layers and neurons accumulate
hyperphosphorylated Tau (pTau) and degenerate early while others remain unaffected even …
hyperphosphorylated Tau (pTau) and degenerate early while others remain unaffected even …
Non-coding RNAs involved in the molecular pathology of Alzheimer's disease: a systematic review
RJ Canoy, JC Sy, CD Deguit, CB Castro… - Frontiers in …, 2024 - frontiersin.org
Alzheimer's disease (AD) is the leading cause of dementia globally, having a
pathophysiology that is complex and multifactorial. Recent findings highlight the significant …
pathophysiology that is complex and multifactorial. Recent findings highlight the significant …
Identification of SH2 domain-containing proteins and motifs prediction by a deep learning method
D Wu, X Fang, K Luan, Q Xu, S Lin, S Sun… - Computers in Biology …, 2023 - Elsevier
Abstract The Src Homology 2 (SH2) domain plays an important role in the signal
transmission mechanism in organisms. It mediates the protein-protein interactions based on …
transmission mechanism in organisms. It mediates the protein-protein interactions based on …
Human isogenic cells of the neurovascular unit exert transcriptomic cell type-specific effects on a blood-brain barrier in vitro model of late-onset Alzheimer disease
U Haferkamp, C Hartmann, CL Abid, A Brachner… - Fluids and Barriers of …, 2023 - Springer
Background The function of the blood-brain barrier (BBB) is impaired in late-onset Alzheimer
disease (LOAD), but the associated molecular mechanisms, particularly with respect to the …
disease (LOAD), but the associated molecular mechanisms, particularly with respect to the …
Clinical and molecular findings in a Turkish family who had a (c. 869-1G> A) splicing variant in PSEN1 gene with a rare condition: the variant alzheimer's disease with …
Background: Early-onset Alzheimer's disease (EOAD) is commonly diagnosed with an onset
age of earlier than 65 years and accounts for 5–10% of all Alzheimer's disease (AD) cases …
age of earlier than 65 years and accounts for 5–10% of all Alzheimer's disease (AD) cases …