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C9orf72-mediated ALS and FTD: multiple pathways to disease
The discovery that repeat expansions in the C9orf72 gene are a frequent cause of
amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) has revolutionized …
amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) has revolutionized …
An update on genetic frontotemporal dementia
Frontotemporal dementia (FTD) is a highly heritable group of neurodegenerative disorders,
with around 30% of patients having a strong family history. The majority of that heritability is …
with around 30% of patients having a strong family history. The majority of that heritability is …
Frontotemporal dementia, where do we stand? A narrative review
Frontotemporal dementia (FTD) is a neurodegenerative disease of growing interest, since it
accounts for up to 10% of middle-age-onset dementias and entails a social, economic, and …
accounts for up to 10% of middle-age-onset dementias and entails a social, economic, and …
Uncovering the heterogeneity and temporal complexity of neurodegenerative diseases with Subtype and Stage Inference
The heterogeneity of neurodegenerative diseases is a key confound to disease
understanding and treatment development, as study cohorts typically include multiple …
understanding and treatment development, as study cohorts typically include multiple …
Serum neurofilament light chain protein is a measure of disease intensity in frontotemporal dementia
Objective: To investigate serum neurofilament light chain (NfL) concentrations in
frontotemporal dementia (FTD) and to see whether they are associated with the severity of …
frontotemporal dementia (FTD) and to see whether they are associated with the severity of …
Converging mechanisms in ALS and FTD: disrupted RNA and protein homeostasis
Breakthrough discoveries identifying common genetic causes for amyotrophic lateral
sclerosis (ALS) and frontotemporal dementia (FTD) have transformed our view of these …
sclerosis (ALS) and frontotemporal dementia (FTD) have transformed our view of these …
C9orf72 BAC mouse model with motor deficits and neurodegenerative features of ALS/FTD
To define how the C9orf72 GGGGCC expansion mutation causes ALS/FTD and to facilitate
therapy development, a mouse model that recapitulates the molecular and phenotypic …
therapy development, a mouse model that recapitulates the molecular and phenotypic …
The C9orf72 GGGGCC Repeat Is Translated into Aggregating Dipeptide-Repeat Proteins in FTLD/ALS
Expansion of a GGGGCC hexanucleotide repeat upstream of the C9orf72 coding region is
the most common cause of familial frontotemporal lobar degeneration and amyotrophic …
the most common cause of familial frontotemporal lobar degeneration and amyotrophic …
[HTML][HTML] Presymptomatic cognitive and neuroanatomical changes in genetic frontotemporal dementia in the Genetic Frontotemporal dementia Initiative (GENFI) study …
Background Frontotemporal dementia is a highly heritable neurodegenerative disorder. In
about a third of patients, the disease is caused by autosomal dominant genetic mutations …
about a third of patients, the disease is caused by autosomal dominant genetic mutations …
Thalamic pathology and memory loss in early Alzheimer's disease: moving the focus from the medial temporal lobe to Papez circuit
It is widely assumed that incipient protein pathology in the medial temporal lobe instigates
the loss of episodic memory in Alzheimer's disease, one of the earliest cognitive deficits in …
the loss of episodic memory in Alzheimer's disease, one of the earliest cognitive deficits in …