Synaptic abnormalities are a cardinal feature of Alzheimer's disease (AD) that are known to
arise as the disease progresses. A growing body of evidence suggests that pathological …

Background: Several studies suggested an important role of the gut microbiota in the
pathophysiology of neurological disorders, implying that alteration of the gut microbiota …

Alzheimer's disease (AD) is a neurodegenerative disease whose various pathophysiological
aspects are still being investigated. Recently, it has been hypothesized that AD may be …

The gut microbiota and its short chain fatty acid (SCFA) metabolites have been established
to play an important protective role against neurodegenerative diseases. Our previous study …

Postoperative cognitive dysfunction (POCD) is a common disorder following surgery, which
seriously threatens the quality of patients' life, especially the older people. Accumulating …

Mental disorders and neurological diseases are becoming a rapidly increasing medical
burden. Although extensive studies have been conducted, the progress in develo** …

The" holobiont" concept, defined as the collective contribution of the eukaryotic and
prokaryotic counterparts to the multicellular organism, introduces a complex definition of …

A complex bidirectional communication system exists between the gastrointestinal tract and
the brain. Initially termed the “gut-brain axis” it is now renamed the “microbiota-gut-brain …

Major depression is one of the leading causes of disability, morbidity, and mortality
worldwide. The brain–gut axis functions are disturbed, revealed by a dysfunction of the …

The terminology “gut-brain axis “points out a bidirectional relationship between the GI
system and the central nervous system (CNS). To date, several researches have shown that …