REM sleep behaviour disorder

Y Dauvilliers, CH Schenck, RB Postuma… - Nature reviews Disease …, 2018 - nature.com
Rapid eye movement (REM) sleep behaviour disorder (RBD) is a parasomnia that is
characterized by loss of muscle atonia during REM sleep (known as REM sleep without …

Melatonin as a hormone: new physiological and clinical insights

J Cipolla-Neto, FG Amaral - Endocrine reviews, 2018 - academic.oup.com
Melatonin is a ubiquitous molecule present in almost every live being from bacteria to
humans. In vertebrates, besides being produced in peripheral tissues and acting as an …

Risk and predictors of dementia and parkinsonism in idiopathic REM sleep behaviour disorder: a multicentre study

RB Postuma, A Iranzo, M Hu, B Högl, BF Boeve… - Brain, 2019 - academic.oup.com
Idiopathic REM sleep behaviour disorder (iRBD) is a powerful early sign of Parkinson's
disease, dementia with Lewy bodies, and multiple system atrophy. This provides an …

The nasal and gut microbiome in Parkinson's disease and idiopathic rapid eye movement sleep behavior disorder

A Heintz‐Buschart, U Pandey, T Wicke… - Movement …, 2018 - Wiley Online Library
Background Increasing evidence connects the gut microbiota and the onset and/or
phenotype of Parkinson's disease (PD). Differences in the abundances of specific bacterial …

Idiopathic REM sleep behaviour disorder and neurodegeneration—an update

B Högl, A Stefani, A Videnovic - Nature Reviews Neurology, 2018 - nature.com
So-called idiopathic rapid eye movement (REM) sleep behaviour disorder (RBD), formerly
seen as a rare parasomnia, is now recognized as the prodromal stage of an α …

Advances in markers of prodromal Parkinson disease

RB Postuma, D Berg - Nature Reviews Neurology, 2016 - nature.com
Efforts to develop neuroprotective therapy for Parkinson disease (PD) are focusing on the
early stages of disease, which offer the best opportunity to intervene. Early PD can be …

Melatonin: clinical perspectives in neurodegeneration

DP Cardinali - Frontiers in endocrinology, 2019 - frontiersin.org
Prevention of neurodegenerative diseases is presently a major goal for our Society and
melatonin, an unusual phylogenetically conserved molecule present in all aerobic …

Delayed emergence of a parkinsonian disorder or dementia in 81% of older men initially diagnosed with idiopathic rapid eye movement sleep behavior disorder: a 16 …

CH Schenck, BF Boeve, MW Mahowald - Sleep medicine, 2013 - Elsevier
Objective To provide a 16-year update from the authors' 1996 report documenting a 38%
conversion from idiopathic rapid eye movement sleep behavior disorder (iRBD) to a …

Parkinson risk in idiopathic REM sleep behavior disorder: preparing for neuroprotective trials

RB Postuma, JF Gagnon, JA Bertrand… - Neurology, 2015 - AAN Enterprises
Objective: To precisely delineate clinical risk factors for conversion from idiopathic REM
sleep behavior disorder (RBD) to Parkinson disease, dementia with Lewy bodies, and …

Prevalence and determinants of rapid eye movement sleep behavior disorder in the general population

J Haba-Rubio, B Frauscher, P Marques-Vidal, J Toriel… - Sleep, 2018 - academic.oup.com
Abstract Study Objectives Rapid eye movement (REM) sleep behavior disorder (RBD) is a
parasomnia associated with neurodegenerative synucleinopathies. Its prevalence is largely …