The Hedgehog signalling pathway has crucial roles in embryonic tissue patterning,
postembryonic tissue regeneration, and cancer, yet aspects of Hedgehog signal …

Cell-cell communication through evolutionarily conserved signaling pathways governs
embryonic development and adult tissue homeostasis. Deregulation of these signaling …

The adult zebrafish heart has a high capacity for regeneration following injury. However, the
composition of the regenerative niche has remained largely elusive. Here, we dissected the …

In vertebrates, sterols are necessary for Hedgehog signaling, a pathway critical in
embryogenesis and cancer. Sterols activate the membrane protein Smoothened by binding …

Hedgehog (Hh) signaling is a highly conserved pathway that plays a vital role during
embryonic development. Recently, uncontrolled activation of this pathway has been …

Developmental signals of the Hedgehog (Hh) and Wnt families are transduced across the
membrane by Frizzled-class G-protein-coupled receptors (GPCRs) composed of both a …

Breast cancer is the most common form of cancer diagnosed in women worldwide and the
second leading cause of cancer-related deaths in the USA. Despite the development of …

The Hedgehog (HH) signaling pathway was discovered originally as a key pathway in
embryonic patterning and development. Since its discovery, it has become increasingly …

β-arrestin1 (or arrestin2) and β-arrestin2 (or arrestin3) are ubiquitously expressed cytosolic
adaptor proteins that were originally discovered for their inhibitory role in G protein–coupled …

Hedgehog signalling is fundamental to embryonic development and postnatal tissue
regeneration. Aberrant postnatal Hedgehog signalling leads to several malignancies …