As an evolutionarily conserved signalling network, the Hippo pathway plays a crucial role in
the regulation of numerous biological processes. Thus, substantial efforts have been made …

Combination therapies are superior to monotherapy for many cancers. This advantage was
historically ascribed to the ability of combinations to address tumor heterogeneity, but …

Simple Summary The mitogen-activated protein kinase/extracellular signal-regulated kinase
(MAPK/ERK) signaling pathway is frequently activated in liver cancer, which is one of the …

Oncolytic viruses (OVs) represent a new class of multi-modal immunotherapies for cancer,
with OV-elicited antitumor immunity being key to their overall therapeutic efficacy. Currently …

Simple Summary Over the past decade, cell-based immunotherapy has become a powerful
strategy in solid cancer therapy. Tumor-infiltrating lymphocytes (TILs) are a group of …

The recent US Food and Drug Administration (FDA) approval of the dabrafenib/trametinib
combination as a tissue-agnostic treatment for solid tumors with BRAF V600E mutation is the …

The RAF family of kinases includes key activators of the pro-tumourigenic mitogen-activated
protein kinase pathway. Hyperactivation of RAF proteins, particularly BRAF and CRAF …

Neuroendocrine neoplasms (NENs) comprise well-differentiated neuroendocrine tumors
(NETs) and poorly differentiated neuroendocrine carcinomas (NECs). Treatment options for …

(1) Background: The oncology field has drastically changed with the advent of precision
medicine, led by the discovery of druggable genes or immune targets assessed through next …

The previous edition of The Bethesda System for Reporting Thyroid Cytopathology provided
important updates and advances in the practice of thyroid cytopathology. It was inspired by …