Strategies to capitalize on cell spheroid therapeutic potential for tissue repair and disease modeling

KH Griffin, SW Fok, J Kent Leach - NPJ Regenerative Medicine, 2022 - nature.com
Cell therapies offer a tailorable, personalized treatment for use in tissue engineering to
address defects arising from trauma, inefficient wound repair, or congenital malformation …

Engineered biomaterials to guide spheroid formation, function, and fabrication into 3D tissue constructs

N Di Caprio, JA Burdick - Acta biomaterialia, 2023 - Elsevier
Cellular spheroids are aggregates of cells that are being explored to address fundamental
biological questions and as building blocks for engineered tissues. Spheroids possess …

Injectable MSC spheroid and microgel granular composites for engineering tissue

ND Caprio, MD Davidson, AC Daly… - Advanced …, 2024 - Wiley Online Library
Many cell types require direct cell–cell interactions for differentiation and function; yet, this
can be challenging to incorporate into 3‐dimensional (3D) structures for the engineering of …

Multisized photoannealable microgels regulate cell spreading, aggregation, and macrophage phenotype through microporous void space

JM Lowen, GC Bond, KH Griffin… - Advanced …, 2023 - Wiley Online Library
Microgels are an emerging platform for in vitro models and guiding cell fate due to their
inherent porosity and tunability. This work describes a light‐based technique for rapidly …

Building a tissue: Mesenchymal and epithelial cell spheroids mechanical properties at micro-and nanoscale

NV Kosheleva, YM Efremov, PI Koteneva, IV Ilina… - Acta Biomaterialia, 2023 - Elsevier
Cell transitions between the epithelial and mesenchymal phenotypes provide the regulated
morphogenesis and regeneration throughout the ontogenesis. The tissue mechanics and …

Label-Free Imaging of Mesenchymal Stem Cell Spheroid Differentiation with Flexible-Probe SECM and a Microfluidic Device

L Zhao, L Wang, J Huang, H Chen, L Liu… - Analytical …, 2024 - ACS Publications
Mesenchymal stem cells (MSCs) have emerged as an indispensable source for stem cell
research and preclinical studies due to their capacity for in vitro proliferation and their …

Microplastic-induced inhibition of cell adhesion and toxicity evaluation using human dermal fibroblast-derived spheroids

S Eom, W Shim, I Choi - Journal of Hazardous Materials, 2024 - Elsevier
Nanoplastics and microplastics (MPs) can significantly affect marine ecosystems and pose
potential risks to human health. Although adverse effects stemming from direct exposure to …

Odontogenesis‐Empowered Extracellular Vesicles Safeguard Donor‐Recipient Stem Cell Interplay to Support Tooth Regeneration

X Huang, B Sui, A Liu, H Guo, C Zheng, P Liu, X Cai… - Small, 2024 - Wiley Online Library
Harnessing the developmental events of mesenchymal condensation to direct postnatal
dental stem cell aggregation represents a cutting‐edge and promising approach to tooth …

Functionalized Annealed Microgels for Spatial Control of Osteogenic and Chondrogenic Differentiation

JM Lowen, EE Wheeler, NK Shimamoto… - Advanced Functional …, 2024 - Wiley Online Library
The biophysical heterogeneity of the bone–cartilage interface requires complex materials to
mimic differences in bone density, extracellular matrix composition, and mineralization …

[HTML][HTML] Mechanoregulation of MSC spheroid immunomodulation

VL Thai, S Mierswa, KH Griffin, JD Boerckel… - APL …, 2024 - pubs.aip.org
Mesenchymal stromal cells (MSCs) are widely used in cell-based therapies and tissue
regeneration for their potent secretome, which promotes host cell recruitment and modulates …