Monocarboxylates such as lactate, pyruvate, and the ketone bodies play major roles in
metabolism and must be transported across both the plasma membrane and mitochondrial …

This review considers how our understanding of preimplantation embryo metabolism has
progressed since the pioneering work on this topic in the late 1960s and early 1970s …

The success of clinical IVF was initially compromised by sub-optimal culture conditions,
resulting in impaired embryo development (1–6) and a subsequent loss of viability …

Background Neuro-glial interactions are important for normal functioning of the brain as well
as brain energy metabolism. There are two major working models-in the classical view, both …

The oocyte, sperm and preimplantation embryo have unique metabolic needs that must be
met to ensure successful pregnancy. The family of facilitative glucose transporters (GLUTs) …

Unicellular organisms are exquisitely sensitive to nutrient availability in the environment and
have evolved elaborate mechanisms to sense the levels and types of nutrients, altering …

Offspring of diabetic mothers are susceptible to the onset of metabolic syndromes, such as
type 2 diabetes and obesity at adulthood, and this trend can be inherited between …

STUDY QUESTION What is the effect of the ketone β-hydroxybutyrate (βOHB) on
preimplantation mouse embryo development, metabolism, epigenetics and post-transfer …

Maintenance of stable pH is important for optimizing gamete and embryo culture. One
method to stabilize pH entails using zwitterionic buffers in IVF handling media used outside …

At times we encounter clinical problems for which there are no directly applicable evidence-
based solutions, but we are compelled by circumstances to act. When doing so we rely on …