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Innate metabolic responses against viral infections
CS Palmer - Nature Metabolism, 2022 - nature.com
Metabolic adaptation to viral infections critically determines the course and manifestations of
disease. At the systemic level, a significant feature of viral infection and inflammation that …
disease. At the systemic level, a significant feature of viral infection and inflammation that …
Viral hijacking of cellular metabolism
This review discusses the current state of the viral metabolism field and gaps in knowledge
that will be important for future studies to investigate. We discuss metabolic rewiring caused …
that will be important for future studies to investigate. We discuss metabolic rewiring caused …
A phase 3, randomized trial of bulevirtide in chronic hepatitis D
Background Coinfection with hepatitis D virus (HDV) accelerates the progression of liver
disease associated with chronic hepatitis B. Bulevirtide inhibits the entry of HDV into …
disease associated with chronic hepatitis B. Bulevirtide inhibits the entry of HDV into …
Hepatitis B virus molecular biology and pathogenesis
As obligate intracellular parasites, viruses need a host cell to provide a milieu favorable to
viral replication. Consequently, viruses often adopt mechanisms to subvert host cellular …
viral replication. Consequently, viruses often adopt mechanisms to subvert host cellular …
First-in-human application of the novel hepatitis B and hepatitis D virus entry inhibitor myrcludex B
A Blank, C Markert, N Hohmann, A Carls, G Mikus… - Journal of …, 2016 - Elsevier
Background & Aims Myrcludex B is a first-in-class compound, which blocks entry of hepatitis
B and D virus into hepatocytes in vitro and in animal models. Based on the required …
B and D virus into hepatocytes in vitro and in animal models. Based on the required …
Proliferation of primary human hepatocytes and prevention of hepatitis B virus reinfection efficiently deplete nuclear cccDNA in vivo
L Allweiss, T Volz, K Giersch, J Kah, G Raffa… - Gut, 2018 - gut.bmj.com
Objective The stability of the covalently closed circular DNA (cccDNA) in nuclei of non-
dividing hepatocytes represents a key determinant of HBV persistence. Contrarily, studies …
dividing hepatocytes represents a key determinant of HBV persistence. Contrarily, studies …
[PDF][PDF] A targeted functional RNA interference screen uncovers glypican 5 as an entry factor for hepatitis B and D viruses
ER Verrier, CC Colpitts, C Bach, L Heydmann… - …, 2016 - Wiley Online Library
Chronic hepatitis B and D infections are major causes of liver disease and hepatocellular
carcinoma worldwide. Efficient therapeutic approaches for cure are absent. Sharing the …
carcinoma worldwide. Efficient therapeutic approaches for cure are absent. Sharing the …
Bile acids in physiology, pathology and pharmacology
Bile acids, synthesized by hepatocytes from cholesterol, are specific and quantitatively
important organic components of bile, where they are the main driving force of the osmotic …
important organic components of bile, where they are the main driving force of the osmotic …
[PDF][PDF] Hepatitis B virus infection and decreased risk of nonalcoholic fatty liver disease: a cohort study
The presence of an association between chronic hepatitis B virus (HBV) infection and fatty
liver is controversial. We examined the association between HBV infection and the …
liver is controversial. We examined the association between HBV infection and the …
The Smc5/6 complex restricts HBV when localized to ND10 without inducing an innate immune response and is counteracted by the HBV X protein shortly after …
C Niu, CM Livingston, L Li, RK Beran, S Daffis… - PloS one, 2017 - journals.plos.org
The structural maintenance of chromosome 5/6 complex (Smc5/6) is a restriction factor that
represses hepatitis B virus (HBV) transcription. HBV counters this restriction by expressing …
represses hepatitis B virus (HBV) transcription. HBV counters this restriction by expressing …