Innate metabolic responses against viral infections

CS Palmer - Nature Metabolism, 2022 - nature.com
Metabolic adaptation to viral infections critically determines the course and manifestations of
disease. At the systemic level, a significant feature of viral infection and inflammation that …

Viral hijacking of cellular metabolism

SK Thaker, J Ch'ng, HR Christofk - BMC biology, 2019 - Springer
This review discusses the current state of the viral metabolism field and gaps in knowledge
that will be important for future studies to investigate. We discuss metabolic rewiring caused …

A phase 3, randomized trial of bulevirtide in chronic hepatitis D

H Wedemeyer, S Aleman, MR Brunetto… - … England Journal of …, 2023 - Mass Medical Soc
Background Coinfection with hepatitis D virus (HDV) accelerates the progression of liver
disease associated with chronic hepatitis B. Bulevirtide inhibits the entry of HDV into …

Hepatitis B virus molecular biology and pathogenesis

RJ Lamontagne, S Bagga, MJ Bouchard - Hepatoma research, 2016 - pmc.ncbi.nlm.nih.gov
As obligate intracellular parasites, viruses need a host cell to provide a milieu favorable to
viral replication. Consequently, viruses often adopt mechanisms to subvert host cellular …

First-in-human application of the novel hepatitis B and hepatitis D virus entry inhibitor myrcludex B

A Blank, C Markert, N Hohmann, A Carls, G Mikus… - Journal of …, 2016 - Elsevier
Background & Aims Myrcludex B is a first-in-class compound, which blocks entry of hepatitis
B and D virus into hepatocytes in vitro and in animal models. Based on the required …

Proliferation of primary human hepatocytes and prevention of hepatitis B virus reinfection efficiently deplete nuclear cccDNA in vivo

L Allweiss, T Volz, K Giersch, J Kah, G Raffa… - Gut, 2018 - gut.bmj.com
Objective The stability of the covalently closed circular DNA (cccDNA) in nuclei of non-
dividing hepatocytes represents a key determinant of HBV persistence. Contrarily, studies …

[PDF][PDF] A targeted functional RNA interference screen uncovers glypican 5 as an entry factor for hepatitis B and D viruses

ER Verrier, CC Colpitts, C Bach, L Heydmann… - …, 2016 - Wiley Online Library
Chronic hepatitis B and D infections are major causes of liver disease and hepatocellular
carcinoma worldwide. Efficient therapeutic approaches for cure are absent. Sharing the …

Bile acids in physiology, pathology and pharmacology

J JG Marin, R IR Macias, O Briz… - Current drug …, 2016 - benthamdirect.com
Bile acids, synthesized by hepatocytes from cholesterol, are specific and quantitatively
important organic components of bile, where they are the main driving force of the osmotic …

[PDF][PDF] Hepatitis B virus infection and decreased risk of nonalcoholic fatty liver disease: a cohort study

EJ Joo, Y Chang, JS Yeom, S Ryu - Hepatology, 2017 - Wiley Online Library
The presence of an association between chronic hepatitis B virus (HBV) infection and fatty
liver is controversial. We examined the association between HBV infection and the …

The Smc5/6 complex restricts HBV when localized to ND10 without inducing an innate immune response and is counteracted by the HBV X protein shortly after …

C Niu, CM Livingston, L Li, RK Beran, S Daffis… - PloS one, 2017 - journals.plos.org
The structural maintenance of chromosome 5/6 complex (Smc5/6) is a restriction factor that
represses hepatitis B virus (HBV) transcription. HBV counters this restriction by expressing …