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Biology-driven therapy advances in high-grade serous ovarian cancer
Following a period of slow progress, the completion of genome sequencing and the
paradigm shift relative to the cell of origin for high grade serous ovarian cancer (HGSOC) led …
paradigm shift relative to the cell of origin for high grade serous ovarian cancer (HGSOC) led …
Development of PARP and immune-checkpoint inhibitor combinations
PARP inhibitors drive increased DNA damage, particularly in tumors with existing defects in
DNA repair. This damage not only promotes immune priming through a range of molecular …
DNA repair. This damage not only promotes immune priming through a range of molecular …
PARP inhibitor upregulates PD-L1 expression and enhances cancer-associated immunosuppression
Purpose: To explore whether a cross-talk exists between PARP inhibition and PD-L1/PD-1
immune checkpoint axis, and determine whether blockade of PD-L1/PD-1 potentiates PARP …
immune checkpoint axis, and determine whether blockade of PD-L1/PD-1 potentiates PARP …
ATR inhibition disrupts rewired homologous recombination and fork protection pathways in PARP inhibitor-resistant BRCA-deficient cancer cells
Poly-(ADP-ribose) polymerase (PARP) inhibitors (PARPis) selectively kill BRCA1/2-deficient
cells, but their efficacy in BRCA-deficient patients is limited by drug resistance. Here, we …
cells, but their efficacy in BRCA-deficient patients is limited by drug resistance. Here, we …
Both fallopian tube and ovarian surface epithelium are cells-of-origin for high-grade serous ovarian carcinoma
The cell-of-origin of high grade serous ovarian carcinoma (HGSOC) remains controversial,
with fallopian tube epithelium (FTE) and ovarian surface epithelium (OSE) both considered …
with fallopian tube epithelium (FTE) and ovarian surface epithelium (OSE) both considered …
Niraparib activates interferon signaling and potentiates anti-PD-1 antibody efficacy in tumor models
PARP inhibitors have been proven clinically efficacious in platinum-responsive ovarian
cancer regardless of BRCA1/2 status and in breast cancers with germline BRCA1/2 …
cancer regardless of BRCA1/2 status and in breast cancers with germline BRCA1/2 …
Cancer vaccines from cryogenically silicified tumour cells functionalized with pathogen-associated molecular patterns
The production of personalized cancer vaccines made from autologous tumour cells could
benefit from mechanisms that enhance immunogenicity. Here we show that cancer vaccines …
benefit from mechanisms that enhance immunogenicity. Here we show that cancer vaccines …
The mammalian ovary from genesis to revelation
Two major functions of the mammalian ovary are the production of germ cells (oocytes),
which allow continuation of the species, and the generation of bioactive molecules, primarily …
which allow continuation of the species, and the generation of bioactive molecules, primarily …
CTLA-4 blockade synergizes therapeutically with PARP inhibition in BRCA1-deficient ovarian cancer
Immune checkpoint blockade has shown significant therapeutic efficacy in melanoma and
other solid tumors, but results in ovarian cancer have been limited. With evidence that tumor …
other solid tumors, but results in ovarian cancer have been limited. With evidence that tumor …
Triple negative tumours: a critical review
Breast cancer is a heterogeneous disease that encompasses several distinct entities with
remarkably different biological characteristics and clinical behaviour. Currently, breast …
remarkably different biological characteristics and clinical behaviour. Currently, breast …