Substantial progress has been made over the past two decades in detecting, predicting and
promoting recovery of consciousness in patients with disorders of consciousness (DoC) …

The process of altering neural activity–neuromodulation–has long been used to treat
patients with brain disorders and answer scientific questions. Deep brain stimulation in …

Imaging intact human organs from the organ to the cellular scale in three dimensions is a
goal of biomedical imaging. To meet this challenge, we developed hierarchical phase …

Deep brain stimulation (DBS) to the fornix is an investigational treatment for patients with
mild Alzheimer's Disease. Outcomes from randomized clinical trials have shown that …

Following its introduction in 2014 and with support of a broad international community, the
open-source toolbox Lead-DBS has evolved into a comprehensive neuroimaging platform …

Multiple surgical targets for treating obsessive-compulsive disorder with deep brain
stimulation (DBS) have been proposed. However, different targets may modulate the same …

To fully understand how the human brain works, knowledge of its structure at high resolution
is needed. Presented here is a computationally intensive reconstruction of the ultrastructure …

Brain cells are arranged in laminar, nuclear, or columnar structures, spanning a range of
scales. Here, we construct a reliable cell census in the frontal lobe of human cerebral cortex …

We present the first three-dimensional (3D) concordance maps of cyto-and fiber architecture
of the human brain, combining histology, immunohistochemistry, and 7-T quantitative …

Dystonia is a debilitating disease with few treatment options. One effective option is deep
brain stimulation (DBS) to the internal pallidum. While cervical and generalized forms of …