Continuous spermatogenesis in post-pubertal mammals is dependent on spermatogonial
stem cells (SSCs), which balance self-renewing divisions that maintain stem cell pool with …

BACKGROUND Infertility is an important side effect of treatments used for cancer and other
non-malignant conditions in males. This may be due to the loss of spermatogonial stem cells …

Spermatogenesis has been intensely studied in rodents but remains poorly understood in
humans. Here, we used single-cell RNA sequencing to analyze human testes. Clustering …

Patients preparing to undergo gonadotoxic medical therapy, radiation therapy, or
gonadectomy should be provided with prompt counseling regarding available options for …

STUDY QUESTION What clinical practices, patient management strategies and
experimental methods are currently being used to preserve and restore the fertility of …

Spermatogonial stem cells (SSCs) are the most primitive spermatogonia in the testis and
have an essential role to maintain highly productive spermatogenesis by self-renewal and …

Spermatogonial stem cells (SSCs) maintain spermatogenesis throughout a man's life and
may have application for treating some cases of male infertility, including those caused by …

Current drug development techniques are expensive and inefficient, partially due to the use
of preclinical models that do not accurately recapitulate in vivo drug efficacy and cytotoxicity …

STUDY QUESTION Is it feasible to disseminate testicular tissue cryopreservation with a
standardized protocol through a coordinated network of centers and provide centralized …

Existing methods for evaluating the potential gonadotoxicity of environmental agents and
pharmaceutical compounds rely heavily on animal studies. The current gold standard in vivo …