The role of the dystrophin glycoprotein complex in muscle cell mechanotransduction

DGS Wilson, A Tinker, T Iskratsch - Communications Biology, 2022 - nature.com
Dystrophin is the central protein of the dystrophin-glycoprotein complex (DGC) in skeletal
and heart muscle cells. Dystrophin connects the actin cytoskeleton to the extracellular matrix …

Evolution and developmental functions of the dystrophin-associated protein complex: Beyond the idea of a muscle-specific cell adhesion complex

V Mirouse - Frontiers in cell and developmental biology, 2023 - frontiersin.org
The Dystrophin-Associated Protein Complex (DAPC) is a well-defined and evolutionarily
conserved complex in animals. DAPC interacts with the F-actin cytoskeleton via dystrophin …

RAD-TGTs: high-throughput measurement of cellular mechanotype via rupture and delivery of DNA tension probes

MR Pawlak, AT Smiley, MP Ramirez, MD Kelly… - Nature …, 2023 - nature.com
Mechanical forces drive critical cellular processes that are reflected in mechanical
phenotypes, or mechanotypes, of cells and their microenvironment. We present here …

Duchenne muscular dystrophy treatment with lentiviral vector containing mini‐dystrophin gene in vivo

X Wang, Y Zhu, T Liu, L Zhou, Y Fu, J Zhao, Y Li… - MedComm, 2024 - Wiley Online Library
Duchenne muscular dystrophy (DMD) is an incurable X‐linked recessive genetic disease
caused by mutations in the dystrophin gene. Many researchers aim to restore truncated …

Systemic treatment of body‐wide Duchenne muscular dystrophy symptoms

P Konieczny - Clinical Pharmacology & Therapeutics, 2024 - Wiley Online Library
Duchenne muscular dystrophy (DMD) is a fatal X‐linked disease that leads to premature
death due to the loss of dystrophin. Current strategies predominantly focus on the …

Dystrophin-and utrophin-based therapeutic approaches for treatment of duchenne muscular dystrophy: a comparative review

S Szwec, Z Kapłucha, JS Chamberlain, P Konieczny - BioDrugs, 2024 - Springer
Duchenne muscular dystrophy is a devastating disease that leads to progressive muscle
loss and premature death. While medical management focuses mostly on symptomatic …

[HTML][HTML] Analysis of common and characteristic actions of Panax ginseng and Panax notoginseng in wound healing based on network pharmacology and meta …

Z Wang, X **e, M Wang, M Ding, S Gu, X **ng… - Journal of Ginseng …, 2023 - Elsevier
In recent years, an increasing number of reports have explored the wound healing
mechanism of these two traditional Chinese herbal medicines-Panax ginseng and Panax …

Ablation of the dystrophin Dp71f alternative C-terminal variant increases sarcoma tumour cell aggressiveness

N Alnassar, J Hajto, RMH Rumney… - Human Molecular …, 2024 - academic.oup.com
Alterations in Dp71 expression, the most ubiquitous dystrophin isoform, have been
associated with patient survival across tumours. Intriguingly, in certain malignancies, Dp71 …

Chiral Cell Nanomechanics Originated in Clockwise/Counterclockwise Biofunctional Microarrays to Govern the Nuclear Mechanotransduction of Mesenchymal Stem …

Y Wang, X Tong, X Shi, T Keswani… - … Applied Materials & …, 2023 - ACS Publications
Cell chirality is extremely important for the evolution of cell morphogenesis to manipulate
cell performance due to left–right asymmetry. Although chiral micro-and nanoscale …

[HTML][HTML] The unconditioned fear response in vertebrates deficient in dystrophin

S Gharibi, C Vaillend, A Lindsay - Progress in Neurobiology, 2024 - Elsevier
Dystrophin loss due to mutations in the Duchenne muscular dystrophy (DMD) gene is
associated with a wide spectrum of neurocognitive comorbidities, including an aberrant …