[HTML][HTML] Microneedles for advanced ocular drug delivery

K Glover, D Mishra, S Gade, LK Vora, Y Wu… - Advanced drug delivery …, 2023 - Elsevier
In the field of ocular drug delivery, topical delivery remains the most common treatment
option for managing anterior segment diseases, while intraocular injections are the current …

Into the tissues: Extracellular matrix and its artificial substitutes: Cell signalling mechanisms

A Bandzerewicz, A Gadomska-Gajadhur - Cells, 2022 - mdpi.com
The existence of orderly structures, such as tissues and organs is made possible by cell
adhesion, ie, the process by which cells attach to neighbouring cells and a supporting …

Candidate pathways for retina to scleral signaling in refractive eye growth

DM Brown, R Mazade, D Clarkson-Townsend… - Experimental eye …, 2022 - Elsevier
The global prevalence of myopia, or nearsightedness, has increased at an alarming rate
over the last few decades. An eye is myopic if incoming light focuses prior to reaching the …

IOP and glaucoma damage: The essential role of optic nerve head and retinal mechanosensors

I Pitha, L Du, TD Nguyen, H Quigley - Progress in retinal and eye research, 2024 - Elsevier
There are many unanswered questions on the relation of intraocular pressure to glaucoma
development and progression. IOP itself cannot be distilled to a single, unifying value …

Innovative nanotechnology in drug delivery systems for advanced treatment of posterior segment ocular diseases

Y Wu, X Li, X Fu, X Huang, S Zhang, N Zhao… - Advanced …, 2024 - Wiley Online Library
Funduscopic diseases, including diabetic retinopathy (DR) and age‐related macular
degeneration (AMD), significantly impact global visual health, leading to impaired vision and …

Posterior scleral birefringence measured by triple-input polarization-sensitive imaging as a biomarker of myopia progression

X Liu, L Jiang, M Ke, IA Sigal, J Chua… - Nature Biomedical …, 2023 - nature.com
In myopic eyes, pathological remodelling of collagen in the posterior sclera has mostly been
observed ex vivo. Here we report the development of triple-input polarization-sensitive …

Nanosuspension-loaded dissolving bilayer microneedles for hydrophobic drug delivery to the posterior segment of the eye

Y Wu, LK Vora, D Mishra, MF Adrianto, S Gade… - Biomaterials …, 2022 - Elsevier
Intravitreal injections (IVT) are regarded as the gold standard for effective delivery of
hydrophobic drugs to the back of the eye. However, as a highly invasive procedure, the …

[HTML][HTML] Optimization of stereolithography 3D printing of microneedle micro-molds for ocular drug delivery

R Fitaihi, S Abukhamees, SH Chung… - International Journal of …, 2024 - Elsevier
Microneedles (MN) have emerged as an innovative technology for drug delivery, offering a
minimally invasive approach to administer therapeutic agents. Recent applications have …

Association between diabetes, diabetic retinopathy, and glaucoma

Y Li, W Mitchell, T Elze, N Zebardast - Current Diabetes Reports, 2021 - Springer
Abstract Purpose of Review The strength of the relationship between diabetes, diabetic
retinopathy (DR), and glaucoma remains controversial. We review evidence supporting and …

[HTML][HTML] Serous business: delineating the broad spectrum of diseases with subretinal fluid in the macula

EHC van Dijk, CJF Boon - Progress in Retinal and Eye Research, 2021 - Elsevier
A wide range of ocular diseases can present with serous subretinal fluid in the macula and
therefore clinically mimic central serous chorioretinopathy (CSC). In this manuscript, we …