Animal behavior is shaped by a variety of" internal states"—partially hidden variables that
profoundly shape perception, cognition, and action. The neural basis of internal states, such …

The breadth and complexity of natural behaviors inspires awe. Understanding how our
perceptions, actions, and internal thoughts arise from evolved circuits in the brain has …

Genetically encoded calcium indicators (GECIs) are powerful tools for systems
neuroscience. Recent efforts in protein engineering have significantly increased the …

Knowing one's own behavioral state has long been theorized as critical for contextualizing
dynamic sensory cues and identifying appropriate future behaviors. Ascending neurons …

Sensory areas are spontaneously active in the absence of sensory stimuli. This
spontaneous activity has long been studied; however, its functional role remains largely …

The internal brain dynamics that link sensation and action are arguably better studied during
natural animal behaviors. Here, we report on a novel volume imaging and 3D tracking …

What are the spatial and temporal scales of brainwide neuronal activity? We used swept,
confocally-aligned planar excitation (SCAPE) microscopy to image all cells in a large …

To increase computational flexibility, the processing of sensory inputs changes with
behavioural context. In the visual system, active behavioural states characterized by motor …

Neurons and neural networks often extend hundreds of micrometers in three dimensions.
Capturing the calcium transients associated with their activity requires volume imaging …

The mouse is emerging as an important model for understanding how sensory neocortex
extracts cues to guide behavior, yet little is known about how these cues are processed …