Background One of the most malignant tumors in men is prostate cancer that is still incurable
due to its heterogenous and progressive natures. Genetic and epigenetic changes play …

Prostate cancer remains a life-threatening disease among men worldwide. The majority of
PCa-related mortality results from metastatic disease that is characterized by metastasis of …

The function of mitophagy in cancer is controversial. ULK1 is critical for induction of
macroautophagy/autophagy and has a more specific role in mitophagy in response to …

Data on gastroenteropancreatic neuroendocrine neoplasms (NEN) G3 (well-differentiated
neuroendocrine tumors (NET G3) and neuroendocrine carcinoma (NEC)) are limited. We …

Bone metastasis is the leading cause of death in prostate cancer patients, for which there is
currently no effective treatment. Since the bone microenvironment plays an important role in …

We developed a rodent model that mimics the osteoblastic and osteolytic changes
associated with human metastatic prostate cancer. Microarray analysis identified MMP-7 …

Proteolytic enzymes may serve as promising targets for novel therapeutic treatment
strategies seeking to impede cancer progression and metastasis. One such enzyme is …

Runx2, a bone-specific transcriptional regulator, is abnormally expressed in highly
metastatic prostate cancer cells. Here, we identified the functional activities of Runx2 in …

Advanced prostate cancer (PCa) often develops bone metastasis, for which therapies are
very limited and the underlying mechanisms are poorly understood. We report that bone …

CC chemokine ligand 2 (CCL2, also known as monocyte chemoattractant protein-1) has
been demonstrated to recruit monocytes to tumor sites. Monocytes are capable of being …