Significance: Epigenetic inactivation of pivotal genes involved in cell growth is a hallmark of
human pathologies, in particular cancer. Histone acetylation balance obtained through …

Acetylation of histone lysine residues occurs in different organisms ranging from yeast to
plants and mammals for the regulation of diverse cellular processes. With the identification …

Context Progesterone resistance, a known pathologic condition associated with a reduced
cellular response to progesterone and heightened estrogen responses, appears to have a …

Diabetic nephropathy (DN) is referred to as the microvascular complication of the kidneys
induced by insufficient production of insulin or an ineffective cellular response to insulin, and …

Recent studies have found a link between deep vein thrombosis and inflammatory reactions.
N6-methyladenosine (m6A), a crucial element in immunological regulation, is believed to …

Both clinical and laboratory studies have demonstrated that different types of physical
exercise may alleviate Parkinsonism yet evidence for complete restoration of motor function …

Background: Type 2 diabetes mellitus (T2DM) is characterized by insulin resistance,
hyperinsulinaemia and hyperglycaemia. Increased glucose production through abnormally …

Recent studies have found a link between deep vein thrombosis and inflammatory reactions.
N6-methyladenosine (m6A), a crucial element in immunological regulation, is believed to …

Objective: In this study, we aimed to analyze the expression levels of specific genes that may
contribute to the pathogenesis of multiple sclerosis (MS) in patients and explore the …

As sirtuínas são uma família de proteínas dependentes do NAD+ com atividade de
desacetilase e ADP-ribosiltransferase. Na Saccharomyces cerevisiae, mosca da fruta …