Doxorubicin: the good, the bad and the ugly effect
The anthracycline doxorubicin (DOX) is widely used in chemotherapy due to its efficacy in
fighting a wide range of cancers such as carcinomas, sarcomas and hematological cancers …
fighting a wide range of cancers such as carcinomas, sarcomas and hematological cancers …
Modulation of cardiac contractility by the phopholamban/SERCA2a regulatome
EG Kranias, RJ Hajjar - Circulation research, 2012 - Am Heart Assoc
Heart disease remains the leading cause of death and disability in the Western world.
Current therapies aim at treating the symptoms rather than the subcellular mechanisms …
Current therapies aim at treating the symptoms rather than the subcellular mechanisms …
Large potentials of small heat shock proteins
Modern classification of the family of human small heat shock proteins (the so-called HSPB)
is presented, and the structure and properties of three members of this family are analyzed …
is presented, and the structure and properties of three members of this family are analyzed …
Insights on human small heat shock proteins and their alterations in diseases
B Tedesco, R Cristofani, V Ferrari, M Cozzi… - Frontiers in molecular …, 2022 - frontiersin.org
The family of the human small Heat Shock Proteins (HSPBs) consists of ten members of
chaperones (HSPB1-HSPB10), characterized by a low molecular weight and capable of …
chaperones (HSPB1-HSPB10), characterized by a low molecular weight and capable of …
Cardiac cAMP-PKA signaling compartmentalization in myocardial infarction
AS Colombe, G Pidoux - Cells, 2021 - mdpi.com
Under physiological conditions, cAMP signaling plays a key role in the regulation of cardiac
function. Activation of this intracellular signaling pathway mirrors cardiomyocyte adaptation …
function. Activation of this intracellular signaling pathway mirrors cardiomyocyte adaptation …
PDE4-mediated cAMP signalling
BA Fertig, GS Baillie - Journal of cardiovascular development and …, 2018 - mdpi.com
cAMP is the archetypal and ubiquitous second messenger utilised for the fine control of
many cardiovascular cell signalling systems. The ability of cAMP to elicit cell surface …
many cardiovascular cell signalling systems. The ability of cAMP to elicit cell surface …
Blockade of Hsp20 phosphorylation exacerbates cardiac ischemia/reperfusion injury by suppressed autophagy and increased cell death
J Qian, X Ren, X Wang, P Zhang, WK Jones… - Circulation …, 2009 - Am Heart Assoc
Rationale: The levels of a small heat shock protein (Hsp) 20 and its phosphorylation are
increased on ischemic insults, and overexpression of Hsp20 protects the heart against …
increased on ischemic insults, and overexpression of Hsp20 protects the heart against …
Phospholamban interactome in cardiac contractility and survival: A new vision of an old friend
K Haghighi, P Bidwell, EG Kranias - Journal of molecular and cellular …, 2014 - Elsevier
Depressed sarcoplasmic reticulum (SR) calcium cycling, reflecting impaired SR Ca-transport
and Ca-release, is a key and universal characteristic of human and experimental heart …
and Ca-release, is a key and universal characteristic of human and experimental heart …
Disruption of the cyclic AMP phosphodiesterase-4 (PDE4)–HSP20 complex attenuates the β-agonist induced hypertrophic response in cardiac myocytes
The small heat shock protein HSP20 is known to be cardioprotective during times of stress
and the mechanism underlying its protective abilities depends on its phosphorylation on …
and the mechanism underlying its protective abilities depends on its phosphorylation on …
Small heat shock protein 20 (HspB6) in cardiac hypertrophy and failure
Hsp20, referred to as HspB6, is constitutively expressed in various tissues. Specifically,
HspB6 is most highly expressed in different types of muscle including vascular, airway …
HspB6 is most highly expressed in different types of muscle including vascular, airway …