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Inhibitors of bacterial immune systems: discovery, mechanisms and applications
To contend with the diversity and ubiquity of bacteriophages and other mobile genetic
elements, bacteria have developed an arsenal of immune defence mechanisms. Bacterial …
elements, bacteria have developed an arsenal of immune defence mechanisms. Bacterial …
Controlling and enhancing CRISPR systems
Many bacterial and archaeal organisms use clustered regularly interspaced short
palindromic repeats–CRISPR associated (CRISPR–Cas) systems to defend themselves …
palindromic repeats–CRISPR associated (CRISPR–Cas) systems to defend themselves …
Structure-based functional mechanisms and biotechnology applications of anti-CRISPR proteins
CRISPR loci and Cas proteins provide adaptive immunity in prokaryotes against invading
bacteriophages and plasmids. In response, bacteriophages have evolved a broad spectrum …
bacteriophages and plasmids. In response, bacteriophages have evolved a broad spectrum …
Discovery of multiple anti-CRISPRs highlights anti-defense gene clustering in mobile genetic elements
Many prokaryotes employ CRISPR–Cas systems to combat invading mobile genetic
elements (MGEs). In response, some MGEs have developed strategies to bypass immunity …
elements (MGEs). In response, some MGEs have developed strategies to bypass immunity …
Phage anti-CRISPR control by an RNA-and DNA-binding helix–turn–helix protein
In all organisms, regulation of gene expression must be adjusted to meet cellular
requirements and frequently involves helix–turn–helix (HTH) domain proteins. For instance …
requirements and frequently involves helix–turn–helix (HTH) domain proteins. For instance …
Structures and strategies of anti-CRISPR-mediated immune suppression
More than 50 protein families have been identified that inhibit CRISPR (clustered regularly
interspaced short palindromic repeats)-Cas-mediated adaptive immune systems. Here, we …
interspaced short palindromic repeats)-Cas-mediated adaptive immune systems. Here, we …
Unveil the secret of the bacteria and phage arms race
Bacteria have developed different mechanisms to defend against phages, such as
preventing phages from being adsorbed on the surface of host bacteria; through the …
preventing phages from being adsorbed on the surface of host bacteria; through the …
Anti-CRISPRs go viral: the infection biology of CRISPR-Cas inhibitors
Bacteriophages encode diverse anti-CRISPR (Acr) proteins that inhibit CRISPR-Cas
immunity during infection of their bacterial hosts. Although detailed mechanisms have been …
immunity during infection of their bacterial hosts. Although detailed mechanisms have been …
Antibiotics that affect translation can antagonize phage infectivity by interfering with the deployment of counter-defenses
It is becoming increasingly clear that antibiotics can both positively and negatively impact
the infectivity of bacteriophages (phage), but the underlying mechanisms often remain …
the infectivity of bacteriophages (phage), but the underlying mechanisms often remain …
Discovery of potent and versatile CRISPR–Cas9 inhibitors engineered for chemically controllable genome editing
Anti-CRISPR (Acr) proteins are encoded by many mobile genetic elements (MGEs) such as
phages and plasmids to combat CRISPR–Cas adaptive immune systems employed by …
phages and plasmids to combat CRISPR–Cas adaptive immune systems employed by …