The issue of heterogeneity of MSC-based advanced therapy medicinal products–a review

AB Česnik, U Švajger - Frontiers in Cell and Developmental Biology, 2024 - frontiersin.org
Mesenchymal stromal stem cells (MSCs) possess a remarkable potential for numerous
clinical applications due to their unique properties including self-renewal …

Advances in exosomes utilization for clinical applications in cancer

IA Batista, JC Machado, SA Melo - Trends in cancer, 2024 - cell.com
Exosomes are regarded as having transformative potential for clinical applications.
Exosome-based liquid biopsies offer a noninvasive method for early cancer detection and …

Mesenchymal stem cell-derived extracellular vesicles: a potential therapy for diabetes mellitus and diabetic complications

F Sun, Y Sun, F Wu, W Xu, H Qian - Pharmaceutics, 2022 - mdpi.com
As a novel cell-free strategy, mesenchymal stem cell-derived extracellular vesicles (MSC-
EVs) inherit the therapeutic potential of donor cells, and are widely used for the treatment of …

The latest developments in immunomodulation of mesenchymal stem cells in the treatment of intrauterine adhesions, both allogeneic and autologous

J Chen, Q Huang, Y Zhao, W Chen, S Lin… - Frontiers in …, 2021 - frontiersin.org
Intrauterine adhesion (IUA) is an endometrial fibrosis disease caused by repeated
operations of the uterus and is a common cause of female infertility. In recent years …

Mesenchymal stem cell therapy for COVID-19 infection

SMM Alavi-Dana, Y Gholami, M Meghdadi… - …, 2024 - Springer
COVID-19 emerged in December 2019 in Wuhan, China, spread worldwide rapidly, and
caused millions of deaths in a short time. Many preclinical and clinical studies were …

GMP‐compliant manufacturing of biologically active cell‐derived vesicles produced by extrusion technology

HC Lau, DW Han, J Park, E Lehner… - Journal of …, 2022 - Wiley Online Library
Extracellular vesicles (EVs) released by a variety of cell types have been shown to act as a
natural delivery system for bioactive molecules such as RNAs and proteins. EV therapy …

Skin-Derived ABCB5+ Mesenchymal Stem Cells for High-Medical-Need Inflammatory Diseases: From Discovery to Entering Clinical Routine

E Niebergall-Roth, NY Frank, C Ganss… - International Journal of …, 2022 - mdpi.com
The ATP-binding cassette superfamily member ABCB5 identifies a subset of skin-resident
mesenchymal stem cells (MSCs) that exhibit potent immunomodulatory and wound healing …

Strategies of macrophages to maintain bone homeostasis and promote bone repair: a narrative review

Y Hu, J Huang, C Chen, Y Wang, Z Hao… - Journal of Functional …, 2022 - mdpi.com
Bone homeostasis (a healthy bone mass) is regulated by maintaining a delicate balance
between bone resorption and bone formation. The regulation of physiological bone …

When origin matters: properties of mesenchymal stromal cells from different sources for clinical translation in kidney disease

S Calcat-i-Cervera, C Sanz-Nogués, T O'Brien - Frontiers in Medicine, 2021 - frontiersin.org
Advanced therapy medicinal products (ATMPs) offer new prospects to improve the treatment
of conditions with unmet medical needs. Kidney diseases are a current major health concern …

Advancing wound healing by hydrogel-based dressings loaded with cell-conditioned medium: a systematic review

G Nifontova, S Safaryan, Y Khristidis… - Stem cell research & …, 2024 - Springer
Background Wound healing represents a complex biological process, critically important in
clinical practice due to its direct implication in a patient's recovery and quality of life …