The issue of heterogeneity of MSC-based advanced therapy medicinal products–a review
AB Česnik, U Švajger - Frontiers in Cell and Developmental Biology, 2024 - frontiersin.org
Mesenchymal stromal stem cells (MSCs) possess a remarkable potential for numerous
clinical applications due to their unique properties including self-renewal …
clinical applications due to their unique properties including self-renewal …
Advances in exosomes utilization for clinical applications in cancer
Exosomes are regarded as having transformative potential for clinical applications.
Exosome-based liquid biopsies offer a noninvasive method for early cancer detection and …
Exosome-based liquid biopsies offer a noninvasive method for early cancer detection and …
Mesenchymal stem cell-derived extracellular vesicles: a potential therapy for diabetes mellitus and diabetic complications
F Sun, Y Sun, F Wu, W Xu, H Qian - Pharmaceutics, 2022 - mdpi.com
As a novel cell-free strategy, mesenchymal stem cell-derived extracellular vesicles (MSC-
EVs) inherit the therapeutic potential of donor cells, and are widely used for the treatment of …
EVs) inherit the therapeutic potential of donor cells, and are widely used for the treatment of …
The latest developments in immunomodulation of mesenchymal stem cells in the treatment of intrauterine adhesions, both allogeneic and autologous
J Chen, Q Huang, Y Zhao, W Chen, S Lin… - Frontiers in …, 2021 - frontiersin.org
Intrauterine adhesion (IUA) is an endometrial fibrosis disease caused by repeated
operations of the uterus and is a common cause of female infertility. In recent years …
operations of the uterus and is a common cause of female infertility. In recent years …
Mesenchymal stem cell therapy for COVID-19 infection
COVID-19 emerged in December 2019 in Wuhan, China, spread worldwide rapidly, and
caused millions of deaths in a short time. Many preclinical and clinical studies were …
caused millions of deaths in a short time. Many preclinical and clinical studies were …
GMP‐compliant manufacturing of biologically active cell‐derived vesicles produced by extrusion technology
HC Lau, DW Han, J Park, E Lehner… - Journal of …, 2022 - Wiley Online Library
Extracellular vesicles (EVs) released by a variety of cell types have been shown to act as a
natural delivery system for bioactive molecules such as RNAs and proteins. EV therapy …
natural delivery system for bioactive molecules such as RNAs and proteins. EV therapy …
Skin-Derived ABCB5+ Mesenchymal Stem Cells for High-Medical-Need Inflammatory Diseases: From Discovery to Entering Clinical Routine
E Niebergall-Roth, NY Frank, C Ganss… - International Journal of …, 2022 - mdpi.com
The ATP-binding cassette superfamily member ABCB5 identifies a subset of skin-resident
mesenchymal stem cells (MSCs) that exhibit potent immunomodulatory and wound healing …
mesenchymal stem cells (MSCs) that exhibit potent immunomodulatory and wound healing …
Strategies of macrophages to maintain bone homeostasis and promote bone repair: a narrative review
Y Hu, J Huang, C Chen, Y Wang, Z Hao… - Journal of Functional …, 2022 - mdpi.com
Bone homeostasis (a healthy bone mass) is regulated by maintaining a delicate balance
between bone resorption and bone formation. The regulation of physiological bone …
between bone resorption and bone formation. The regulation of physiological bone …
When origin matters: properties of mesenchymal stromal cells from different sources for clinical translation in kidney disease
Advanced therapy medicinal products (ATMPs) offer new prospects to improve the treatment
of conditions with unmet medical needs. Kidney diseases are a current major health concern …
of conditions with unmet medical needs. Kidney diseases are a current major health concern …
Advancing wound healing by hydrogel-based dressings loaded with cell-conditioned medium: a systematic review
G Nifontova, S Safaryan, Y Khristidis… - Stem cell research & …, 2024 - Springer
Background Wound healing represents a complex biological process, critically important in
clinical practice due to its direct implication in a patient's recovery and quality of life …
clinical practice due to its direct implication in a patient's recovery and quality of life …