The mRNA coding sequence defines not only the amino acid sequence of the protein, but
also the speed at which the ribosomes move along the mRNA while making the protein. The …

In vitro transcribed, modified messenger RNAs (IVTmRNAs) have been used to vaccinate
billions of individuals against the SARS-CoV-2 virus, and are currently being developed for …

Synonymous gene recoding, the substitution of synonymous variants into the genetic
sequence, has been used to overcome many production limitations in therapeutic …

Coagulation factor IX plays a central role in hemostasis through interaction with factor VIIIa
to form a factor X–activating complex at the site of injury. The absence of factor IX activity …

Monoclonal antibodies (mAbs) are commonly used biologic therapeutics with a wide variety
of clinical applications. During the development process, manufacturers consider different …

Human genetic disorders are often caused by mutations of compound heterozygosity, where
each allele of the mutant gene harbors a different genetic lesion. However, studies of such …

Hemophilia B (HB) is an inherited bleeding disorder caused by defects in the FⅨ gene,
leading to severe coagulation dysfunction. This study designed eight pairs of primers …

Tetracycline-inducible systems are widely used control elements for mammalian gene
expression. Despite multiple iterations to improve inducibility, their use is still compromised …

The possibility of constructing synthetic genomes represents a groundbreaking frontier in
synthetic biology, enabling researchers to design, build, and manipulate genetic material in …

Le cancer du sein est le cancer le plus diagnostiqué dans le monde, et le plus meurtrier
chez la femme. 70% des cas sont caractérisés par l'expression du récepteur aux …